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Prognostic Significance of HLA Class I Expressing in Gastric Carcinoma Defined by Monoclonal Anti-Pan HLA Class I Antibody, EMR8-5

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Introduction

Downregulation or loss of HLA class I molecules has been demonstrated in human cancers. The aim of this study was to assess the clinical significance of HLA class I expression in gastric cancer.

Methods

Gastric cancer tissues from 189 patients were examined for expression of HLA class I heavy chain antigens by immunohistochemical staining with EMR8-5. The expression level of HLA class I of tumor cells is categorized by combining an estimate the percentage of immunoreactive cell with an estimate of the staining intensity. The relationship between HLA class I expression and clinicopathologic parameters, patient survival, and tumor recurrence were analyzed.

Results

HLA class I was downregulated in 85 (45.0%) of the gastric carcinomas. Staining revealed 104 (55.0%) tumors with strongly positive expression of HLA class I antigens, 76 (40.2%) tumors with weakly positive expression, and 9 (4.8%) tumors with negative expression. The expression of HLA class I antigen did not correlate with any other clinicopathologic parameters. Moreover, HLA class I expression was neither a risk factor for tumor recurrence nor survival.

Conclusion

The downregulation of HLA class I expression is not associated with patient prognosis.

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Acknowledgments

This work was supported by a grant no. 01-2008-06 from the Hallym University Medical Center Research Fund.

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Authors and Affiliations

  1. Department of Surgery, Hallym University Hangang Sacred Heart Hospital, 94-200, Yeongdeungpo-dong, Yeongdeungpo-gu, Seoul, 150-719, South Korea

    Hae-Wan Lee

  2. Department of Pathology, Hallym University Sacred Heart Hospital, 896 Pyungchon-dong, Dongan-gu, Anyang-si, Kyungki-do, 431–070, Seoul, South Korea

    Soo Kee Min

  3. Department of Occupation and Environmental Medicine, Hallym University Sacred Heart Hospital, 896 Pyungchon-dong, Dongan-gu, Anyang-si, Kyungki-do, 431-070, Seoul, South Korea

    Young-Su Ju

  4. Department of Epidemiology, Seoul National University School of Public Health, 599 Gwanak-no, Gwanak-gu, Seoul, 151-742, South Korea

    Joohon Sung

  5. Department of Surgery, Hallym University Sacred Heart Hospital, 896 Pyungchon-dong, Dongan-gu, Anyang-si, Kyungki-do, 431–070, Seoul, South Korea

    Man Sup Lim & Bong Hwa Lee

  6. Department of Surgery, Hallym University, Kangnam Sacred Heart Hospital, 948-1, Daerim-dong, Yeongdeungpo-gu, Seoul, 150-950, South Korea

    Dae Hyun Yang

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  1. Hae-Wan Lee
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Correspondence to Hae-Wan Lee.

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Lee, HW., Min, S.K., Ju, YS. et al. Prognostic Significance of HLA Class I Expressing in Gastric Carcinoma Defined by Monoclonal Anti-Pan HLA Class I Antibody, EMR8-5. J Gastrointest Surg 15, 1336–1343 (2011). https://doi.org/10.1007/s11605-011-1545-3

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  • DOI: https://doi.org/10.1007/s11605-011-1545-3

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