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Prognostic Factors for Post-recurrence Survival in Esophageal Squamous Cell Carcinoma Patients with Recurrence after Resection

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Objective

The survival of recurrent esophageal cancer is poor. But reports regarding prognostic factors for post-recurrence survival are limited. We analyzed the recurrence pattern and the prognostic factors for post-recurrence survival in esophageal squamous cell carcinoma with recurrence after resection.

Methods

Two hundred sixty-eight patients were included. Tumor recurrence occurred in 115 (42.9%) patients. Recurrence pattern was classified as locoregional, distant, and combined recurrence. The post-recurrence survival was defined as the interval between initial recurrence and either death or the last follow-up.

Results

Mediastinum lymphadenopathy was the most common site for locoregional recurrence, whereas lung, liver, and bone were the most common sites for distant recurrence. The overall 1- and 2-year post-recurrence survival rates were 32.6% and 12.6% with a median survival after recurrence of 6.0 months. The independent prognostic factors included liver recurrence (HR = 2.255, 95%CI = 1.073–4.741, p = 0.032), time to recurrence ≤10 months (HR = 2.657, 95%CI = 1.438–4.911, p = 0.002), and no treatment for recurrences (HR = 2.745, 95%CI = 1.635–4.608, p < 0.001).

Conclusions

We identify liver recurrence, early recurrence, and no treatment for recurrence as risk factors for dismal post-recurrence survival.

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Authors and Affiliations

  1. Department of Surgery, Chutung Veterans Hospital, Hsinchu County, Taiwan

    Po-Kuei Hsu

  2. Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan

    Po-Kuei Hsu

  3. School of Medicine, National Yang-Ming University, Taipei, Taiwan

    Po-Kuei Hsu, Bing-Yen Wang, Chien-Sheng Huang, Yu-Chung Wu & Wen-Hu Hsu

  4. Division of Thoracic Surgery, Department of Surgery, Taipei-Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei, Taiwan

    Po-Kuei Hsu, Bing-Yen Wang, Chien-Sheng Huang, Yu-Chung Wu & Wen-Hu Hsu

  5. School of Medicine, Taipei Medical University, Taipei, Taiwan

    Wen-Hu Hsu

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  1. Po-Kuei Hsu
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  2. Bing-Yen Wang
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Correspondence to Wen-Hu Hsu.

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Hsu, PK., Wang, BY., Huang, CS. et al. Prognostic Factors for Post-recurrence Survival in Esophageal Squamous Cell Carcinoma Patients with Recurrence after Resection. J Gastrointest Surg 15, 558–565 (2011). https://doi.org/10.1007/s11605-011-1458-1

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  • DOI: https://doi.org/10.1007/s11605-011-1458-1

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