Skip to main content

Advertisement

Log in

Minimally Invasive Total Gastrectomy for Gastric Cancer: A Pilot Series

  • Original Article
  • Published:
Journal of Gastrointestinal Surgery Aims and scope

Abstract

Background

Minimally invasive surgery for select gastrointestinal disease has gained worldwide acceptance. However, laparoscopic total gastrectomy for cancer remains controversial. The purpose of this study was to examine an initial experience with laparoscopic total gastrectomy.

Methods

Medical records of 16 consecutive patients who underwent laparoscopic total gastrectomy between September 2007 and December 2009 were reviewed in a retrospective manner. Esophagojejunostomy was completed using a transorally delivered anvil, with double-stapled esophageal anastomosis.

Results

There were no conversions to open procedures. Two patients (12.5%) required extended resections with en bloc distal pancreatectomy and splenectomy, one of whom also underwent transverse colectomy. The median lymph node count for patients who underwent D2 lymphadenectomy (n = 12) for gastric adenocarcinoma was 31. There were no perioperative deaths and the median length of stay was 8 days. There were no anastomotic leaks, but three patients developed anastomotic strictures amenable to dilatation.

Conclusions

Minimally invasive total gastrectomy can be performed safely and with adequate lymphadenectomy. The procedure provides an excellent short-term outcome with potential for improved patient outcome.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. The Clinical Outcomes of Surgical Therapy Study Group, A comparison of laparoscopically assisted and open colectomy for colon cancer. N Engl J Med, 2004. 350(20): p. 2050–9.

    Article  Google Scholar 

  2. Hayashi, H., T. Ochiai, H. Shimada, et al., Prospective randomized study of open versus laparoscopy-assisted distal gastrectomy with extraperigastric lymph node dissection for early gastric cancer. Surg Endosc, 2005. 19(9): p. 1172–6.

    Article  PubMed  CAS  Google Scholar 

  3. Huscher, C.G., A. Mingoli, G. Sgarzini, et al., Laparoscopic versus open subtotal gastrectomy for distal gastric cancer: 5-year results of a randomized prospective trial. Ann Surg, 2005. 241(2): p. 232–7.

    Article  PubMed  Google Scholar 

  4. Kitano, S., N. Shiraishi, K. Fujii, et al., A randomized controlled trial comparing open vs laparoscopy-assisted distal gastrectomy for the treatment of early gastric cancer: an interim report. Surgery, 2002. 131(1 Suppl): p. S306–11.

    Article  PubMed  Google Scholar 

  5. Lee, J.H. and H.S. Han, A prospective randomized study comparing open vs laparoscopy-assisted distal gastrectomy in early gastric cancer: early results. Surg Endosc, 2005. 19(2): p. 168–73.

    Article  PubMed  Google Scholar 

  6. Strong, V.E., N. Devaud, P.J. Allen, et al., Laparoscopic versus open subtotal gastrectomy for adenocarcinoma: a case-control study. Ann Surg Oncol, 2009. 16(6): p. 1507–13.

    Article  PubMed  Google Scholar 

  7. Guzman, E.A., A. Pigazzi, B. Lee, et al., Totally laparoscopic gastric resection with extended lymphadenectomy for gastric adenocarcinoma. Ann Surg Oncol, 2009. 16(8): p. 2218–23.

    Article  PubMed  Google Scholar 

  8. Uyama, I., A. Sugioka, J. Fujita, et al., Laparoscopic total gastrectomy with distal pancreatosplenectomy and D2 lymphadenectomy for advanced gastric cancer. Gastric Cancer, 1999. 2(4): p. 230–4.

    Article  PubMed  Google Scholar 

  9. Usui, S., T. Yoshida, K. Ito, et al., Laparoscopy-assisted total gastrectomy for early gastric cancer: comparison with conventional open total gastrectomy. Surg Laparosc Endosc Percutan Tech, 2005. 15(6): p. 309–14.

    Article  PubMed  Google Scholar 

  10. Topal, B., E. Leys, N. Ectors, et al., Determinants of complications and adequacy of surgical resection in laparoscopic versus open total gastrectomy for adenocarcinoma. Surg Endosc, 2008. 22(4): p. 980–4.

    Article  PubMed  CAS  Google Scholar 

  11. Shinohara, T., S. Kanaya, K. Taniguchi, et al., Laparoscopic total gastrectomy with D2 lymph node dissection for gastric cancer. Arch Surg, 2009. 144(12): p. 1138–42.

    Article  PubMed  Google Scholar 

  12. Nguyen, N.T., M.W. Hinojosa, B.R. Smith, et al., Advances in circular stapling technique for gastric bypass: Transoral placement of the anvil. Obesity Surgery, 2008. 18(5): p. 611–4.

    Article  PubMed  Google Scholar 

  13. Nguyen, T.N., M.W. Hinojosa, B.R. Smith, et al., Thoracoscopic construction of an intrathoracic esophagogastric anastomosis using a circular stapler: transoral placement of the anvil. Ann Thorac Surg, 2008. 86(3): p. 989–92.

    Article  PubMed  Google Scholar 

  14. Ke, C.W., D.L. Chen, D. Ding, et al., [A new technique for esophagojejunostomy or esophagogastrostomy after laparoscopic gastrectomy]. Zhonghua Wei Chang Wai Ke Za Zhi, 2010. 13(1): p. 29–32.

    PubMed  Google Scholar 

  15. Anderson, C., J. Ellenhorn, M. Hellan, et al., Pilot series of robot-assisted laparoscopic subtotal gastrectomy with extended lymphadenectomy for gastric cancer. Surg Endosc, 2007. 21(9): p. 1662–6.

    Article  PubMed  Google Scholar 

  16. Jeong, O. and Y.K. Park, Intracorporeal circular stapling esophagojejunostomy using the transorally inserted anvil (OrVil) after laparoscopic total gastrectomy. Surg Endosc, 2009. 23: p. 2624–30.

    Article  PubMed  Google Scholar 

  17. Lacy, A.M., J.C. Garcia-Valdecasas, S. Delgado, et al., Laparoscopy-assisted colectomy versus open colectomy for treatment of non-metastatic colon cancer: a randomised trial. Lancet, 2002. 359(9325): p. 2224–9.

    Article  PubMed  Google Scholar 

  18. Jayne, D.G., P.J. Guillou, H. Thorpe, et al., Randomized trial of laparoscopic-assisted resection of colorectal carcinoma: 3-year results of the UK MRC CLASICC Trial Group. J Clin Oncol, 2007. 25(21): p. 3061–8.

    Article  PubMed  Google Scholar 

  19. Schulze, S. and J. Thorup, Pulmonary function, pain, and fatigue after laparoscopic cholecystectomy. Eur J Surg, 1993. 159(6–7): p. 361–4.

    PubMed  CAS  Google Scholar 

  20. Iwanaka, T., M.S. Arkovitz, G. Arya, et al., Evaluation of operative stress and peritoneal macrophage function in minimally invasive operations. J Am Coll Surg, 1997. 184(4): p. 357–63.

    PubMed  CAS  Google Scholar 

  21. Gupta, A. and D.I. Watson, Effect of laparoscopy on immune function. Br J Surg, 2001. 88(10): p. 1296–306.

    Article  PubMed  CAS  Google Scholar 

  22. Carter, J.J. and R.L. Whelan, The immunologic consequences of laparoscopy in oncology. Surg Oncol Clin N Am, 2001. 10(3): p. 655–77.

    PubMed  CAS  Google Scholar 

  23. Goh, P., Y. Tekant, C.K. Kum, et al., Totally intra-abdominal laparoscopic Billroth II gastrectomy. Surg Endosc, 1992. 6(3): p. 160.

    Article  PubMed  CAS  Google Scholar 

  24. Liakakos, T., E.P. Misiakos, and A. Macheras, Advanced gastric cancer: is laparoscopic gastrectomy safe? Surg Endosc, 2009. 23: p. 1161–3.

    Article  PubMed  CAS  Google Scholar 

  25. Azagra, J.S., M. Goergen, P. De Simone, et al., Minimally invasive surgery for gastric cancer. Surg Endosc, 1999. 13(4): p. 351–7.

    Article  PubMed  CAS  Google Scholar 

  26. Kim, Y.W., Y.H. Baik, Y.H. Yun, et al., Improved quality of life outcomes after laparoscopy-assisted distal gastrectomy for early gastric cancer: results of a prospective randomized clinical trial. Ann Surg, 2008. 248(5): p. 721–7.

    Article  PubMed  Google Scholar 

  27. Kim, H.H., W.J. Hyung, G.S. Cho, et al., Morbidity and mortality of laparoscopic gastrectomy versus open gastrectomy for gastric cancer: an interim report--a phase III multicenter, prospective, randomized Trial (KLASS Trial). Ann Surg, 2010. 251(3): p. 417–20.

    Article  PubMed  Google Scholar 

  28. Edil, B.H., Is laparoscopic total gastrectomy the right operation? Arch Surg, 2009. 144(12): p. 1143.

    Article  PubMed  Google Scholar 

  29. Japanese Gastric Cancer Association, Japanese classification of gastric carcinoma—2nd English edition. Gastric Cancer, 1998. 1(1): p. 10–24.

    Article  PubMed  Google Scholar 

  30. Siewert, J.R., K. Bottcher, H.J. Stein, et al., Relevant prognostic factors in gastric cancer: 10-year results of the German Gastric Cancer Study. Ann Surg, 1998. 228(4): p. 449–61.

    Article  PubMed  CAS  Google Scholar 

  31. Anderson, C., M. Hellan, K. Kernstine, et al., Robotic surgery for gastrointestinal malignancies. Int J Med Robot, 2007. 3(4): p. 297–300.

    PubMed  CAS  Google Scholar 

  32. Song, J., H.J. Lee, G.S. Cho, et al., Recurrence following laparoscopy-assisted gastrectomy for gastric cancer: a multicenter retrospective analysis of 1,417 patients. Ann Surg Oncol, 2010. 17: p. 1777–86.

    Article  PubMed  Google Scholar 

  33. Pugliese, R., D. Maggioni, F. Sansonna, et al., Total and subtotal laparoscopic gastrectomy for adenocarcinoma. Surg Endosc, 2007. 21(1): p. 21–7.

    Article  PubMed  CAS  Google Scholar 

  34. Patriti, A., G. Ceccarelli, R. Bellochi, et al., Robot-assisted laparoscopic total and partial gastric resection with D2 lymph node dissection for adenocarcinoma. Surg Endosc, 2008. 22(12): p. 2753–60.

    Article  PubMed  Google Scholar 

  35. Steele, K.E., G.P. Prokopowicz, T. Magnuson, et al., Laparoscopic antecolic Roux-en-Y gastric bypass with closure of internal defects leads to fewer internal hernias than the retrocolic approach. Surg Endosc, 2008. 22(9): p. 2056–61.

    Article  PubMed  CAS  Google Scholar 

  36. Bauman, R.W. and J.R. Pirrello, Internal hernia at Petersen’s space after laparoscopic Roux-en-Y gastric bypass: 6.2% incidence without closure--a single surgeon series of 1047 cases. Surg Obes Relat Dis, 2009. 5(5): p. 565–70.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Joshua D. I. Ellenhorn.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kachikwu, E.L., Trisal, V., Kim, J. et al. Minimally Invasive Total Gastrectomy for Gastric Cancer: A Pilot Series. J Gastrointest Surg 15, 81–86 (2011). https://doi.org/10.1007/s11605-010-1356-y

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11605-010-1356-y

Keywords

Navigation