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A Meta-Analysis of Randomized Controlled Trials that Compared Laparoscopy-Assisted and Open Distal Gastrectomy for Early Gastric Cancer

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Background

We conducted a meta-analysis to evaluate and compare the advantages of laparoscopy-assisted distal gastrectomy (LADG) over open distal gastrectomy (ODG) for treating early gastric cancer (EGC).

Methods

We searched MEDLINE, EMBASE, Science Citation Index, and Cochrane Controlled Trial Register for relevant papers published between January 1990 and January 2010 by using the following search terms: laparoscopy-assisted gastrectomy, laparoscopic gastrectomy, and early gastric cancer. The following data were analyzed: operative time, estimated blood loss, number of harvested lymph nodes, time required for resumption of oral intake, duration of hospital stay, frequency of analgesic administration, complications, tumor recurrence, and mortality.

Results

We selected four papers reporting randomized control studies (RCTs) that compared LADG with ODG for EGC. Our meta-analysis included 267 patients with EGC; of these, 134 and 133 had undergone LADG and ODG, respectively. The volume of intraoperative blood loss, frequency of analgesic administration, and rate of complications were significantly lesser for LADG than for ODG. However, the time required for resumption of oral intake and duration of hospital stay did not significantly differ between LADG and ODG. The operative time for LADG was significantly longer than that for ODG; further, the number of harvested lymph nodes was significantly lesser in the LADG group than in the ODG group.

Conclusion

LADG is advantageous over ODG because it results in lesser blood loss, is less painful, and is associated with a low risk of complications. Additional RCTs that compare LADG and ODG and investigate the long-term oncological outcomes of LADG are required to determine the advantages of LADG over ODG.

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Authors and Affiliations

  1. Department of Surgery, Osaka City Sumiyoshi Hospital, 1-2-16, Higashi-Kagaya, Suminoe-ku, Osaka, 559-0012, Japan

    Hiroshi Ohtani, Yutaka Tamamori, Kozo Noguchi & Takashi Azuma

  2. Department of Gastroenterology, Osaka City Sumiyoshi Hospital, Osaka, Japan

    Shunsuke Fujimoto, Hiroko Oba & Tetsuya Aoki

  3. Department of Internal Medicine, Osaka City Sumiyoshi Hospital, Osaka, Japan

    Mieko Minami

  4. Department of Surgical Oncology, Osaka City University Graduate School of Medicine, Osaka, Japan

    Kosei Hirakawa

Authors
  1. Hiroshi Ohtani
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  2. Yutaka Tamamori
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  3. Kozo Noguchi
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  4. Takashi Azuma
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  5. Shunsuke Fujimoto
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  6. Hiroko Oba
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  7. Tetsuya Aoki
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  8. Mieko Minami
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  9. Kosei Hirakawa
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Corresponding author

Correspondence to Hiroshi Ohtani.

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Ohtani, H., Tamamori, Y., Noguchi, K. et al. A Meta-Analysis of Randomized Controlled Trials that Compared Laparoscopy-Assisted and Open Distal Gastrectomy for Early Gastric Cancer. J Gastrointest Surg 14, 958–964 (2010). https://doi.org/10.1007/s11605-010-1195-x

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  • DOI: https://doi.org/10.1007/s11605-010-1195-x

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