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Use of Positron Emission Tomography in Surgery Follow-Up of Esophageal Cancer

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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Introduction

Although the prognosis of patients with esophageal cancer has been improved by extended dissection, the incidence of recurrence still remains high. In esophageal cancer, positron emission tomography (PET) using 18F-fluorodeoxyglucose (FDG) already demonstrated to be useful for initial staging and monitoring response to therapy. This prospective study compared the ability of FDG-PET and conventional imaging to detect early recurrence of esophageal cancer after initial surgery in asymptomatic patients.

Materials and Methods

Between October 2003 and September 2006, 41 patients with esophageal cancer were included in a prospective study after initial radical esophagectomy. FDG-PET, thoracoabdominal computed tomography (CT), abdominal ultrasonography, and endoscopy were performed every 6 months after initial treatment.

Results and Discussion

Twenty-three patients had recurrent disease (56%), mostly within the first 6 months after surgery (70%). Despite two false-positive scans due to postoperative changes, FDG-PET was more accurate than CT (91% vs. 81%, p = 0.02) for the detection of recurrence with a sensitivity of 100% (vs. 65%), a specificity of 85% (vs. 91%), and a negative predictive value of 100% on a patient-by-patient-based analysis. For the detection of locoregional recurrence, FDG-PET was more accurate than CT (96.2% vs. 88.9%). FDG-PET was also more accurate than CT for the detection of distant metastases (92.5% vs. 84.9%), especially when involving either bones (100%) or liver (98.1%). A lower sensitivity of FDG-PET (57%) for the early detection of small lung metastases did not affect patient management (accuracy = 92.5%).

Conclusion

FDG-PET appears to be very useful for the systematic follow-up of asymptomatic patients after esophagectomy with an initial scan performed 6 months after surgery.

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Authors and Affiliations

  1. Nuclear Medicine Department, CHU Brest, Morvan Hospital, 29609, Brest, France

    P. Teyton & Catherine Cheze Le Rest

  2. Institute of Oncology, CHU Brest, Morvan Hospital, Brest, France

    J. P. Metges & V. Jestin-Le Tallec

  3. Surgery Department, CHU Brest, Cavale Blanche Hospital, Brest, France

    A. Atmani, J. P. Bail & P. Lozac’h

  4. Anatomopathology Department, CHU Brest, Cavale Blanche Hospital, Brest, France

    A. Volant

  5. INSERM, U650, Laboratoire de Traitement de l’Information Médicale (LaTIM), IFR 148 ScInBioS, Brest, France

    D. Visvikis, O. Pradier & Catherine Cheze Le Rest

  6. Radiotherapy Department, CHU Brest, Morvan Hospital, Brest, France

    O. Pradier

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  1. P. Teyton
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Teyton, P., Metges, J.P., Atmani, A. et al. Use of Positron Emission Tomography in Surgery Follow-Up of Esophageal Cancer. J Gastrointest Surg 13, 451–458 (2009). https://doi.org/10.1007/s11605-008-0749-7

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