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Delineation of the nerve fiber bundles of the infant brain associated with aging using phase difference-enhanced imaging: a preliminary study

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Abstract

Purpose

The purpose of this study was to evaluate the delineation of nerve fiber bundles in the brainstem and optic radiation in infants associated with aging on T1WI, T2WI, and phase difference-enhanced (PADRE) images.

Materials and methods

We retrospectively reviewed 21 consecutive subjects < 2 years old who underwent brain MRI without abnormal imaging findings. Two neuroradiologists evaluated the eight nerve fiber bundles in the brainstem and optic radiation using a 3-point scale focused on the contrast to surrounding brain parenchyma. We also evaluated the signal ratio of the optic radiation to surrounding white matter on PADRE for each month age.

Results

T2WI was able to delineate nerve fiber bundles better than T1WI at 1 month old, and the images gradually became unclear with aging. On PADRE, almost all nerve fiber bundles were unclear or invisible at 1 month old but gradually became clearer with aging. There was a significant negative correlation between age and the signal ratio of the optic radiation to surrounding white matter.

Conclusions

The PADRE imaging was able to delineate the nerve fiber bundles in infants, and the delineation gradually became clearer with aging. The combination of PADRE, T1WI, and T2WI would be useful for evaluation of nerve fiber bundles in infants.

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Abbreviations

PADRE:

Phase difference enhanced

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Acknowledgements

This study was supported by grants from the Kawano Foundation for medical research, Japan, Grant no 27-waka-12 (Yukio Kimura).

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Authors and Affiliations

  1. Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1 Ogawa-Higashi, Kodaira, Tokyo, 187-0031, Japan

    Hiroyuki Fujii, Noriko Sato, Yukio Kimura, Yoko Shigemoto & Fumio Suzuki

  2. Department of Radiology, School of Medicine, Jichi Medical University, Tochigi, Japan

    Hiroyuki Fujii & Hideharu Sugimoto

  3. Department of Neurology, Graduate School of Medicine, Chiba University, Chiba, Japan

    Atsuhiko Sugiyama

  4. Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, Tokyo, Japan

    Hiroshi Matsuda

  5. Department of Child Neurology, National Center of Neurology and Psychiatry, Tokyo, Japan

    Masayuki Sasaki

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  1. Hiroyuki Fujii
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  2. Noriko Sato
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  3. Yukio Kimura
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  4. Atsuhiko Sugiyama
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  9. Hideharu Sugimoto
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Corresponding author

Correspondence to Noriko Sato.

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Fujii, H., Sato, N., Kimura, Y. et al. Delineation of the nerve fiber bundles of the infant brain associated with aging using phase difference-enhanced imaging: a preliminary study. Jpn J Radiol 38, 731–739 (2020). https://doi.org/10.1007/s11604-020-00955-z

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  • DOI: https://doi.org/10.1007/s11604-020-00955-z

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