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Brain-core temperature of patients before and after orthotopic liver transplantation assessed by DWI thermometry

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Abstract

Purpose

To assess brain-core temperature of end-stage liver disease patients undergoing orthotopic liver transplantation (OLT) using a temperature measurement technique based on the apparent diffusion coefficient of the cerebrospinal fluid in the lateral ventricles.

Materials and methods

The study group was composed of 19 patients with a model for end-stage liver disease (MELD) score of 23.7 who underwent MR imaging before and after OLT. MR imaging studies were performed with a 1.5T MR scanner. Brain-core temperature (T: °C) was calculated using the following equation from the apparent diffusion coefficient (D) of the cerebrospinal fluid in the lateral ventricles: \(T = {{2256.74} \mathord{\left/ {\vphantom {{2256.74} {\ln \left( {4.39221/D} \right)}}} \right. \kern-0pt} {\ln \left( {4.39221/D} \right)}}{-}273.15\) measured with a DWI sequence (b value 1000 s/mm2). We compared brain-core temperature of all patients before and after OLT.

Results

Brain-core temperature measurements were successfully taken in all patients before and after OLT. The measured brain-core temperature mean ± standard deviation was 38.67 ± 1.76 °C before OLT and 38.60 ± 0.99 °C after OLT, showing no significant difference (P = 0.643).

Conclusions

Brain-core temperature was stable in patients undergoing OLT. DWI thermometry may provide a supplementary brain biomarker to confirm that cerebral blood flow and metabolism are stable in patients undergoing OLT.

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Abbreviations

ASL:

Arterial spin labeling

CBF:

Cerebral blood flow

CMRO2 :

Cerebral metabolic rate for oxygen

CSF:

Cerebrospinal fluid

DWI:

Diffusion-weighted imaging

FLAIR:

Fluid-attenuated inversion recovery

FSE:

Fast-spin-echo

FOV:

Field of view

LV:

Lateral ventricles

MELD:

Model for end-stage liver disease

MR:

Magnetic resonance

MRI:

Magnetic resonance imaging

OTL:

Orthotopic liver transplantation

PWI:

Perfusion-weighted imaging

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Acknowledgements

We are indebted to Warren Blumberg, science editor at ISMETT, for his help in revising the manuscript.

Funding

The authors received no financial support for the research, authorship, and/or publication of this article.

Author information

Authors and Affiliations

  1. Department of Diagnostic and Therapeutic Services, IRCCS-ISMETT, Via Tricomi, 5, 90127, Palermo, Italy

    Gianvincenzo Sparacia, Giuseppe Mamone & Roberto Miraglia

  2. Department of Radiology, University of Palermo, Palermo, Italy

    Gianvincenzo Sparacia & Roberto Cannella

  3. Neurology Service-IRCCS-ISMETT, Palermo, Italy

    Vincenzina Lo Re

  4. Advanced MR Image Laboratory, Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Koji Sakai

  5. Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Kei Yamada

Authors
  1. Gianvincenzo Sparacia
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  2. Roberto Cannella
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  3. Vincenzina Lo Re
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  4. Giuseppe Mamone
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  5. Koji Sakai
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  7. Roberto Miraglia
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Corresponding author

Correspondence to Gianvincenzo Sparacia.

Ethics declarations

Ethics standards

Our retrospective cohort study was reviewed and approved by the Institutional Research Review Board (IRRB) of our institution, and informed consent form was waived; however, informed written consent to the MR was obtained from all patients. We declare that all human studies have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Conflict of interest

The authors declare that they have no conflict of interest.

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Sparacia, G., Cannella, R., Lo Re, V. et al. Brain-core temperature of patients before and after orthotopic liver transplantation assessed by DWI thermometry. Jpn J Radiol 36, 324–330 (2018). https://doi.org/10.1007/s11604-018-0729-0

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  • DOI: https://doi.org/10.1007/s11604-018-0729-0

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