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Heterogeneity of longitudinal and circumferential contraction in relation to late gadolinium enhancement in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction

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Abstract

Purpose

To evaluate heterogeneity of myocardial contraction in relation to extensive late gadolinium enhancement (LGE) in hypertrophic cardiomyopathy (HCM) patients with preserved left ventricular ejection fraction, using fast strain-encoded magnetic resonance imaging.

Materials and methods

Twenty-two HCM patients and 24 age-matched control subjects were included in this retrospective study. The regional and global peak values of longitudinal and circumferential strain (LSregional, LSglobal, CSregional, CSglobal), and their regional heterogeneities were evaluated using coefficients of variation (LSCoV, CSCoV) in relation to LGE. Receiver operating characteristic curve analysis was performed to identify patients with a total left ventricular myocardial LGE ≥ 15%.

Results

LSglobal in HCM patients was significantly decreased compared to that in controls (− 14.4 ± 2.4% vs − 17.2 ± 2.0%; p = 0.0004), while CSglobal was not (p = 1.0). Negative LGE segments demonstrated decreased LSregional in HCM patients compared to in controls (p < 0.0001), while CSregional was not decreased. CSCoV demonstrated the largest area under the curve (AUC) (0.91), with high sensitivity (83%) and specificity (94%) for detection of HCM patients with extensive LGE, while the AUC of LSCoV was low (0.49).

Conclusion

The heterogeneity in CSregional has a high diagnostic value for detection of HCM patients with extensive LGE.

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Authors and Affiliations

  1. Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Kita1 4, Nishi 5, Kita-ku, Sapporo, 060-8638, Japan

    Keita Sakamoto, Noriko Oyama-Manabe, Yasuka Kikuchi, Kohsuke Kudo & Fumi Kato

  2. Department of Radiation Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Keita Sakamoto & Hiroki Shirato

  3. Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Osamu Manabe

  4. Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Tadao Aikawa, Harue Sasai-Masuko & Masanao Naya

  5. Center for Cause of Death Investigation, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Yasuka Kikuchi

  6. Department of Radiology, Kyoto Prefectural University of Medicine, Kyoto, Japan

    Nagara Tamaki

Authors
  1. Keita Sakamoto
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  2. Noriko Oyama-Manabe
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  3. Osamu Manabe
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  4. Tadao Aikawa
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  6. Harue Sasai-Masuko
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  7. Masanao Naya
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  8. Kohsuke Kudo
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  9. Fumi Kato
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  10. Nagara Tamaki
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  11. Hiroki Shirato
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Corresponding author

Correspondence to Noriko Oyama-Manabe.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee.

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The authors declare that they have no conflict of interest.

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Sakamoto, K., Oyama-Manabe, N., Manabe, O. et al. Heterogeneity of longitudinal and circumferential contraction in relation to late gadolinium enhancement in hypertrophic cardiomyopathy patients with preserved left ventricular ejection fraction. Jpn J Radiol 36, 103–112 (2018). https://doi.org/10.1007/s11604-017-0700-5

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  • DOI: https://doi.org/10.1007/s11604-017-0700-5

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