Abstract
Background
To assess the influence of the hyperintense acute reperfusion marker (HARM) on the relative signal intensity (rSI) and apparent diffusion coefficient (ADC) of hyper-acute ischemic lesions in a canine stroke model.
Methods
Middle cerebral artery occlusion models were established using autologous clot embolization. Diffusion-weighted (DW) and fluid-attenuated inversion recovery (FLAIR) imaging was performed at 1, 2, 3, 4.5 and 6 h after embolization. HARM was defined as the delayed enhancement of cerebrospinal fluid on the subsequent FLAIR images after contrast media used.
Results
Twenty-four stroke models were successfully established and divided into the HARM (n = 16) and No-HARM group (n = 8). No significant differences were found in the rSI on DWI (b0 and b1000 map) and relative ADC between the two groups at each time point after embolization (all P > 0.05). There were no significant differences in the rSI on FLAIR at 1 and 2 h after embolization between the two groups (P > 0.05), while the HARM group showed significantly higher rSI on FLAIR than the No-HARM group at 3, 4.5 and 6 h after embolization (P = 0.044, 0.036 and 0.001, respectively).
Conclusions
HARM should be noted during the quantitative analysis of FLAIR images in future clinical practice.
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Abbreviations
- HARM:
-
Hyperintense acute reperfusion marker
- SI:
-
Signal intensity
- ADC:
-
Apparent diffusion coefficient
- MCAO:
-
Middle cerebral artery occlusion
- DWI:
-
Diffusion-weighted imaging
- FLAIR:
-
Fluid-attenuated inversion recovery
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This research is founded by National Natural Science Foundation of China (81401497 to XQ Xu; 81571777 to HB Shi; 81471764 to S Liu; 81501565 to QQ Zu; 81401383 to SS Lu).
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The authors declared no conflicts of interest.
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X.-Q. Xu, C.-J. Wu and Q.-Q. Zu contributed equally to this work.
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Xu, XQ., Wu, CJ., Zu, QQ. et al. Temporal evolution of the signal intensity of hyper-acute ischemic lesions in a canine stroke model: influence of hyperintense acute reperfusion marker. Jpn J Radiol 35, 161–167 (2017). https://doi.org/10.1007/s11604-017-0615-1
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DOI: https://doi.org/10.1007/s11604-017-0615-1