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Seed migration after transperineal interstitial prostate brachytherapy with I-125 free seeds: analysis of its incidence and risk factors

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Abstract

Purpose

The purpose of this study was to evaluate the incidence and predictors of seed migration after transperineal interstitial prostate brachytherapy.

Materials and methods

From March 2007 to March 2011, 121 patients with stage T1–T2 prostate cancer underwent transperineal interstitial prostate brachytherapy. Pre-planning was performed 3 weeks prior to implantation, and the implants were inserted using the standard parallel needle insertion technique. All patients underwent a series of radiographs [chest radiography, kidney–ureter–bladder (KUB) radiography, and a CT scan] to assess whether seed migration had occurred on postoperative days 1 and 30, and 12 months.

Results

Seed migration occurred in 31 (25.6 %) of 121 patients. A total of 51 of 7,883 (0.65 %) implanted seeds migrated. Migration was detected on postoperative day 1 in 16 patients, day 30 in 13 patients and at 12 months in 4 patients (migration occurred at different times in 2 patients). The migrated seeds were found in the lungs, pelvis, heart, mediastinum, kidney, inguinal canal, liver and sacrum. The number of needles was a statistically significant factor in seed migration.

Conclusions

The seeds migrated to many organs. No decrease in the dose administered to the prostate or adverse effects associated with seed migration were noted.

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Conflict of interest

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Authors and Affiliations

  1. Department of Urology, Kanazawa Medical University, Uchinada, Ishikawa, 920-0293, Japan

    Katsuhito Miyazawa, Nobuyo Morita, Ippei Chikazawa, Kosuke Tokunaga & Koji Suzuki

  2. Department of Diagnostic and Therapeutic Radiology, Kanazawa Medical University, Ishikawa, Japan

    Munetaka Matoba, Kiyotaka Ota & Hisao Tonami

  3. Department of Pathology and Laboratory Medicine, Kanazawa Medical University, Ishikawa, Japan

    Hiroshi Minato & Takayuki Nojima

Authors
  1. Katsuhito Miyazawa
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  2. Munetaka Matoba
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  3. Hiroshi Minato
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  4. Nobuyo Morita
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  5. Ippei Chikazawa
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  6. Kiyotaka Ota
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  7. Kosuke Tokunaga
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  8. Hisao Tonami
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  9. Takayuki Nojima
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  10. Koji Suzuki
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Corresponding author

Correspondence to Katsuhito Miyazawa.

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Miyazawa, K., Matoba, M., Minato, H. et al. Seed migration after transperineal interstitial prostate brachytherapy with I-125 free seeds: analysis of its incidence and risk factors. Jpn J Radiol 30, 635–641 (2012). https://doi.org/10.1007/s11604-012-0102-7

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  • DOI: https://doi.org/10.1007/s11604-012-0102-7

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