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Successful hyperbaric oxygen therapy for laryngeal radionecrosis after chemoradiotherapy for mesopharyngeal cancer: case report and literature review

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Abstract

Laryngeal radionecrosis is one of the most troublesome late complications of radiotherapy, because it is frequently resistant to treatment and laryngectomy is required in the worst case. Here, we report a case of laryngeal radionecrosis, successfully treated by use of hyperbaric oxygen (HBO) therapy, in which laryngectomy was avoided. A 67-year-old male received radical chemoradiotherapy (CRT) for mesopharyngeal cancer, which included radiotherapy with a total dose of 71.4 Gy/38 Fr and chemotherapy with CDDP + S-1. He developed dyspnea and throat pain 9 months after completion of CRT. Laryngoscopy revealed vocal cord impairment because of severe laryngeal edema. He was diagnosed as having laryngeal radionecrosis and initially received conservative therapy combined with antibiotics, steroids, and prostaglandins. Because his dyspnea was persistent despite this treatment, HBO therapy was administered 20 times, and resulted in complete remission of the dyspnea. HBO therapy, therefore, is regarded as an effective conservative therapeutic option for laryngeal radionecrosis.

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References

  1. Marx RE. A new concept in the treatment of osteoradionecrosis. J Oral Maxillofac Surg. 1983;41:351–7.

    Article  PubMed  CAS  Google Scholar 

  2. Filntisis GA, Moon RE, Kraft KL, Farmer JC, Scher RL, Piantadosi CP. Laryngeal radionecrosis and hyperbaric oxygen therapy: report of 18 cases and review of the literature. Ann Otol Rhinol Laryngol. 2000;109:554–62.

    PubMed  CAS  Google Scholar 

  3. Chandler JR. Radiation fibrosis and necrosis of the larynx. Ann Otol Rhinol Laryngol. 1979;88:509–14.

    PubMed  CAS  Google Scholar 

  4. Pasquier D, Holesher T, Schmutz J, Dische S, Mathieu D, Baumann M, et al. Hyperbaric oxygen therapy in the treatment of radio-induced lesions in normal tissues: a literature review. Radiother Oncol. 2004;72:1–13.

    Article  PubMed  CAS  Google Scholar 

  5. Hsu YC, Lee KW, Ho KY, Tsai KB, Kuo WR, Wang LF, et al. Treatment of laryngeal radionecrosis with hyperbaric oxygen therapy: a case report. Kaohsiung J Med Sci. 2005;21:88–92.

    Article  PubMed  Google Scholar 

  6. Narozny W, Sicko Z, Kot J, Stankiewicz C, Przewozny T, Kuczkowski J. Hyperbaric oxygen therapy in the treatment of complications of irradiation in head and neck area. UHM. 2005;32:103–10.

    CAS  Google Scholar 

  7. London SD, Park SS, Gampper TJ, Hoard MA. Hyperbaric oxygen for the management of radionecrosis of bone and cartilage. Laryngoscope. 1998;108:1291–6.

    Article  PubMed  CAS  Google Scholar 

  8. Nishida A, Honda N, Kitani Y, Tsujimura M, Adachi T, Fujiki N, et al. Treatment of laryngeal radionecrosis with hyperbaric oxygen therapy: a case report. Jibirinshou. 2007;100:1021–6.

    Google Scholar 

  9. Matsushita H, Nemoto K, Ogawa Y, Ariga H, Takeda K, Sakayauchi T, et al. Effects of hyperbaric oxygen therapy (HBO) on radiation-induced late sequelae. J Jpn Soc Ther Radiol Oncol. 2007;19:147–55.

    CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Radiology, National Hospital Organization Kyushu Cancer Center, 3-1-1 Notame, Minami-ku, Fukuoka, 811-1395, Japan

    Madoka Abe, Kotaro Terashima & Satoru Uehara

  2. Department of Heavy Particle Therapy and Radiation Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Yoshiyuki Shioyama

  3. Department of Head neck Surgery, National Hospital Organization Kyushu Cancer Center, Fukuoka, Japan

    Mioko Matsuo

  4. Section of Dentistry and Oral Surgery, Keikoukai Hara Hospital, Fukuoka, Japan

    Iwao Hara

Authors
  1. Madoka Abe
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  2. Yoshiyuki Shioyama
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  3. Kotaro Terashima
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  4. Mioko Matsuo
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  5. Iwao Hara
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  6. Satoru Uehara
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Corresponding author

Correspondence to Madoka Abe.

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Abe, M., Shioyama, Y., Terashima, K. et al. Successful hyperbaric oxygen therapy for laryngeal radionecrosis after chemoradiotherapy for mesopharyngeal cancer: case report and literature review. Jpn J Radiol 30, 340–344 (2012). https://doi.org/10.1007/s11604-011-0046-3

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  • DOI: https://doi.org/10.1007/s11604-011-0046-3

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