Skip to main content
SpringerLink
Log in

Simultaneous imaging of magnetic resonance imaging and positron emission tomography by means of MRI-compatible optic fiber-based PET: a validation study in ex vivo rat brain

  • Technical Note
  • Published:
Japanese Journal of Radiology Aims and scope Submit manuscript

Abstract

Purpose

We developed a new type of scintillation detector ring for positron emission tomography (PET). In this device the scintillation detectors were connected with 2.6 m length optic fibers to transport scintillation light to a photomultiplier (PMT) located apart from the detector rings. The present study aimed to test the possibility of simultaneous imaging with PET and magnetic resonance imaging (MRI) by means of the present PET device in ex vivo rat brain.

Materials and methods

The scintillation detector ring of 4 cm diameter was located in a magnetic field of 0.15 T open MRI. Simultaneous measurements of PET and MRI were performed in ex vivo rat brain after injection of 18F-fluorodeoxyglucose (18F-FDG) 37 MBq and 18F-NaF 37 MBq. Simultaneous data acquisition was performed for 10 min for PET and 5 min for T1-weighted MRI.

Results

Simultaneous imaging of PET and MRI was possible without noticeable image distortion in the PET and MRI scans. In the fusion images, high uptake of 18F-FDG was identified in the Harderian glands and striatum. High uptake of 18F-NaF was found in the skull base and vault.

Conclusions

The present study indicated the possibility of simultaneous imaging of PET and MRI by means of optic fiber-based scintillation detectors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Beyer T, Townsend DW, Brun T, Kinahan PE, Charron M, Roddy R, et al. A combined PET/CT scanner for clinical oncology. J Nucl Med 2000;41:1369–1379.

    PubMed  CAS  Google Scholar 

  2. Pichler BJ, Judenhofer MS, Catana C, Walton JH, Kneilling M, Nutt RE, et al. Performance test of an LSO-APD detector in a 7-T MRI scanner for simultaneous PET/MRI. J Nucl Med 2006;47:639–647.

    PubMed  Google Scholar 

  3. Pichler BJ, Wehrl HF, Kolb A, Judenhofer MS. Positron emission tomography/magnetic resonance imaging: the next generation of multimodality imaging? Semin Nucl Med 2008;38:199–208.

    Article  PubMed  Google Scholar 

  4. Judenhofer MS, Catana C, Swann BK, Siegel SB, Jung WI, Nutt RE, et al. PET/MR images acquired with a compact MRcompatible PET detector in a 7-T magnet. Radiology 2007;244:807–814.

    Article  PubMed  Google Scholar 

  5. Schlemmer HP, Pichler BJ, Schmand M, Burbar Z, Michel C, Ladebeck R, et al. Simultaneous MR/PET imaging of the human brain: feasibility study. Radiology 2008;248:1028–1035.

    Article  PubMed  Google Scholar 

  6. Shao Y, Cherry SR, Farahani K, Meadors K, Siegel S, Silverman RW, et al. Simultaneous PET and MR imaging. Phys Med Biol 1997;42:1965–1970.

    Article  PubMed  CAS  Google Scholar 

  7. Yamamoto S, Shimosegawa E, Tasumi M, Higuchi I. Impact of DOI detector and correction for fused images using DOIPET/MRI system. J Nucl Med 2008;49(suppl 1):163P.

    Google Scholar 

  8. Raylman RR, Majewski S, Lemieux SK, Velan SS, Kross B, Popov V, et al. Simultaneous MRI and PET imaging of a rat brain. Phys Med Biol 2006;51:6371–6379.

    Article  PubMed  Google Scholar 

  9. Yamamoto S, Kuroda K, Senda M. Scintillator selection for MR-compatible gamma detectors. I EEE Trans Nucl Sci 2003;50:1683–1685.

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine and Tracer Kinetics, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, 565-0871, Japan

    Masao Imaizumi, Yasukazu Kanai, Eku Shimosegawa & Jun Hatazawa

  2. Department of Electrical Engineering, Kobe City College of Technology, Kobe, Japan

    Seiichi Yamamoto

  3. Hitachi Metals, NEOMAX Co., Ltd, Saga, Japan

    Makoto Kawakami, Masaaki Aoki & Eiji Sugiyama

Authors
  1. Masao Imaizumi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Seiichi Yamamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Makoto Kawakami
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Masaaki Aoki
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Eiji Sugiyama
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Yasukazu Kanai
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Eku Shimosegawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Jun Hatazawa
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Masao Imaizumi.

About this article

Cite this article

Imaizumi, M., Yamamoto, S., Kawakami, M. et al. Simultaneous imaging of magnetic resonance imaging and positron emission tomography by means of MRI-compatible optic fiber-based PET: a validation study in ex vivo rat brain. Jap J Radiol 27, 252–256 (2009). https://doi.org/10.1007/s11604-009-0328-1

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11604-009-0328-1

Key words

Search

Navigation