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Acute toxicity of postoperative IMRT and chemotherapy for endometrial cancer

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Abstract

Purpose

The aim of this study was to determine the acute toxicity of postoperative intensity-modulated radiotherapy (IMRT) with and without chemotherapy in patients with endometrial cancer.

Materials and methods

A total of 19 patients with stages IB–IVB endometrial cancer who underwent surgery and postoperative IMRT were reviewed. The treatment planning goal was to cover the tissue at risk and minimize the dose to the bladder, bowel, and bone marrow. Median dose was 50.4 Gy (range 49.6–51.2 Gy). Altogether, 14 patients underwent chemotherapy; most were given carboplatin and paclitaxel. Toxicity was scored according to the Common Terminology Criteria for Adverse Events version 3.0 (CTCAE).

Results

The prescribed radiation treatment was completed in all patients. The prescribed cycles of chemotherapy were completed in all 14 patients, except one who received five of six cycles limited by prolonged thrombocytopenia. Chemotherapy was delayed in two patients (14%). Three patients required growth factor support during chemotherapy, and one patient required a blood transfusion. Acute grades 3–4 hematological toxicity occurred in 9 of the 14 patients (64%) who underwent chemotherapy. None experienced acute grade 3 or 4 genitourinary or gastrointestinal toxicity.

Conclusion

Adjuvant IMRT and chemotherapy following surgery in patients with endometrial cancer is well tolerated and did not lead to treatment modification in most patients.

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Authors and Affiliations

  1. Department of Radiation Oncology, Box 8224, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4921 Parkview Place, Lower Level, St. Louis, MO, 63110, USA

    Ryan M. Tierney & Perry W. Grigsby

  2. Department of Obstetrics and Gynecology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA

    Matthew A. Powell, David G. Mutch, Randall K. Gibb, Janet S. Rader & Perry W. Grigsby

  3. Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA

    Perry W. Grigsby

  4. Alvin J. Siteman Cancer Center, St. Louis, MO, USA

    Matthew A. Powell, David G. Mutch, Randall K. Gibb, Janet S. Rader & Perry W. Grigsby

Authors
  1. Ryan M. Tierney
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  2. Matthew A. Powell
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  3. David G. Mutch
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  4. Randall K. Gibb
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  5. Janet S. Rader
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  6. Perry W. Grigsby
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Corresponding author

Correspondence to Perry W. Grigsby.

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Tierney, R., Powell, M., Mutch, D. et al. Acute toxicity of postoperative IMRT and chemotherapy for endometrial cancer. Radiat Med 25, 439–445 (2007). https://doi.org/10.1007/s11604-007-0163-1

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  • DOI: https://doi.org/10.1007/s11604-007-0163-1

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