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Association of down-regulation of CD109 expression with up-expression of Smad7 in pathogenesis of psoriasis

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Summary

Transforming growth factor (TGF)-β signaling plays an important role in the pathogenesis of psoriasis. CD109, a novel TGF-β co-receptor, which inhibits TGF-β signaling by enhancing Smad7-dependent degradation of TGF-β type I receptor (TGF-β RI), is abnormally expreβsed in psoriasis. To date, the expreβsion of Smad7 and the correlation between CD109 and Smad7 expreβsion in psoriasis have not been fully elucidated. This study was designed to investigate the expreβsion and the correlation of CD109 and TGF-β signaling aβsociated proteins in psoriasis and their roles in the pathogenesis of psoriasis. Thirty-two psoriasis specimens were subjected to immunohistochemical staining for CD109, Smad7, TGF-β RI and Ki67. Ten normal skin (NS) specimens served as controls. The positive expression rate (% positive cells) of Smad7 and Ki67 in psoriasis was significantly higher than in NS (62.6%±19.9% vs. 17.2%±4.4%, and 50.7%±14.3% vs. 19.5%±3.2%, respectively, P<0.001), and the expression levels of CD109 and TGF-β R? were reduced significantly in psoriasis as compared with NS (8.1%±6.7% vs. 35.8%±6.7% and 27.3%±3.4% vs. 3.0%±3.4%, respectively, P<0.001). There were significantly negative correlations between CD109 and Smad7 (r=-0.831, P<0.01). These findings indicated that CD109 might play a certain role in the pathogenesis of psoriasis. Lower expression of CD109 and TGF-β RI was highly correlated with higher expression of Smad7 and Ki67, suggesting that CD109 may induce the pathogenesis of psoriasis through Smad7-mediated degradation of TGF-β RI, and lead to the termination of TGF-β signaling.

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Authors and Affiliations

  1. Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Xin-xin Liu  (刘欣欣), Ai-ping Feng  (冯爱平), Yi-min He  (和义敏), Yan Li  (李 延), Yan Wu  (吴 艳), Xin Lian  (连 昕), Feng Hu  (胡 枫), Jia-wen Li  (李家文), Ya-ting Tu  (涂亚庭) & Shan-juan Chen  (陈善娟)

Authors
  1. Xin-xin Liu  (刘欣欣)
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  2. Ai-ping Feng  (冯爱平)
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  3. Yi-min He  (和义敏)
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  4. Yan Li  (李 延)
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  5. Yan Wu  (吴 艳)
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  6. Xin Lian  (连 昕)
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  7. Feng Hu  (胡 枫)
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  8. Jia-wen Li  (李家文)
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  9. Ya-ting Tu  (涂亚庭)
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  10. Shan-juan Chen  (陈善娟)
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Correspondence to Shan-juan Chen  (陈善娟).

Additional information

This project was supported by the National Natural Science Foundation of China (No. 81101191, and No. 30972654).

The authors contributed equally to this work.

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Liu, Xx., Feng, Ap., He, Ym. et al. Association of down-regulation of CD109 expression with up-expression of Smad7 in pathogenesis of psoriasis. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 36, 132–136 (2016). https://doi.org/10.1007/s11596-016-1555-1

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  • DOI: https://doi.org/10.1007/s11596-016-1555-1

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