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Association between EGF +61 A>G polymorphism and gastric cancer risk: A meta-analysis

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Summary

Previous studies suggested an association between the EGF +61 A>G polymorphism and susceptibility to gastric cancer, but the results have been inconsistent. To draw a more precise risk estimation of the association, we performed a meta-analysis of published studies. PubMed, EMBASE, Google Scholar and the Chinese Wanfang databases were systematically searched to identify relevant studies. There were 7 studies involving 1992 cases of gastric cancer and 3202 controls in this meta-analysis. Our study showed that, overall, the EGF +61 A>G polymorphism was significantly associated with the increased risk of gastric cancer in allele model (G vs. A: OR=1.18, 95% CI=1.00–1.39), dominant model (GG + GA vs. AA: OR=1.28, 95% CI=1.05–1.55), homozygous model (GG vs. AA: OR=1.31, 95% CI=1.06–1.63) and heterozygous model (GA vs. AA: OR=1.25, 95% CI=1.01–1.53). The stratified analysis by ethnicity revealed a significant association between EGF +61 A>G polymorphism and gastric cancer risks in Asians. This meta-analysis indicates that EGF +61 A>G polymorphism may increase the risk of gastric cancer, especially in Asians. Large-sized, well-designed studies involving different ethnic groups should be conducted to confirm this association.

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Authors and Affiliations

  1. Key Laboratory of Environment and Health, Ministry of Education & Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Song-jie Wu  (吴松杰), Si-yu Jiang  (蒋思宇), Jing Wu  (吴静) & Guang-lian Xiong  (熊光练)

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  1. Song-jie Wu  (吴松杰)
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  2. Si-yu Jiang  (蒋思宇)
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  3. Jing Wu  (吴静)
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  4. Guang-lian Xiong  (熊光练)
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Correspondence to Guang-lian Xiong  (熊光练).

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The two authors contributed equally to this work.

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Wu, Sj., Jiang, Sy., Wu, J. et al. Association between EGF +61 A>G polymorphism and gastric cancer risk: A meta-analysis. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 35, 327–332 (2015). https://doi.org/10.1007/s11596-015-1432-3

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  • DOI: https://doi.org/10.1007/s11596-015-1432-3

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