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Regulation of ω-3 fish oil emulsion on the SIRS during the initial stage of severe acute pancreatitis

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Summary

The aim of this study was to explore the effects of parenteral supplementation with ω-3 fish oil emulsion (Omegaven®) on systemic inflammatory response syndrome (SIRS) during the initial stage of severe acute pancreatitis (SAP). In a prospective, randomized and controlled trial, 60 patients with SAP were randomized either to treat with conventional therapy (Con group, n=30) or conventional therapy plus intravenous supplementation with ω-3 fish oil emulsion 0.2 g/kg every day (FO group, n=30). The effects were analyzed by the SIRS-related indexes. The results showed that APACHE-II scores in FO group were significantly lower, and the gap increased much farther after the 4th day than those in Con group (P<0.05). Fluid equilibrium time became shorter markedly in FO group than in Con group (5.1±2.2 days vs 8.4±2.3 days). In FO group, SIRS scores were markedly decreased and the SIRS state vanished after the 4th day; Plasma level of TNF-α was significantly reduced, while IL-10 decreased markedly, most prominently between the 4th and 7th day, and the ratio of IL-10/TNF-α raised as compared with Con group (P<0.05). During the initial stage of SAP, parenteral supplementation with ω-3 fish oil emulsion could efficiently lower the magnitude and persistence time of the SIRS, markedly retrieve the unbalance of the pro-/anti-inflammatory cytokines, improve severe condition of illness and may provide a new way to regulate the SIRS.

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References

  1. Calder PC. N-3 polyunsaturated fatty acids, inflammation, and inflammatory diseases. Am J Clin Nutr, 2006,83(6 Suppl):1505S–1519S

    PubMed  CAS  Google Scholar 

  2. Bradley EL 3rd. A clinically based classification system for acute pancreatitis: summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga., September 11 through 13, 1992. Arch Surg, 1993,128(5):586–590

    PubMed  Google Scholar 

  3. Ishikawa K, Idoguchi K, Tanaka H, et al. Classification of acute pancreatitis based on retroperitoneal extension: Application of the concept of interfascial planes. European Journal of Radiology, 2006,60(3): 445–452

    Article  PubMed  Google Scholar 

  4. Mitchell RM, Byrne MF, Baillie J. Pancreatitis. Lancet, 2003, 361(9367): 1447–1455

    Article  PubMed  CAS  Google Scholar 

  5. American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit Care Med, 1992, 20(6):864–874

    Google Scholar 

  6. Band S, Singh P, Pooran N, et al. Evaluation of factors that have reduced mortality form acute pancreatitis over the past 20 years. J Clin Gastroenteroi, 2002, 35(1):50

    Article  Google Scholar 

  7. Wang CY. Some important aspects to refine further the treatment of severe acute pancreatitis. Clin J Surg (Chinese), 2006,11(6):11–13

    Google Scholar 

  8. RAU Bettina M. Outcome determinants in acute pancreatitis. Am J Surg, 2007,194:(4 Suppl): S39–S44

    Google Scholar 

  9. Wang CY, Zhao G, Zhang WK, et al. Therapeutic effect and mechanism of ulinastatin on severe acute pancreatitis. Clin J Surg (China), 2000,8(3):172

    CAS  Google Scholar 

  10. Zhou F, Wang CY, Wang CD, et al. Clinical observation of prostaglandin E1 on organ protection in severe acute pancreatitis. Clin J Surg (Chinese), 2004,12(9):540–541

    Google Scholar 

  11. Zhang XP, Zhang L, Chen LJ, et al. Influence of dexamethasone on inflammatory mediators and NF-κB expression in multiple organs of rats with severe acute pancreatitis. World J Gastroenterol, 2007,13(4):548–556

    Article  PubMed  Google Scholar 

  12. Zhang XP, Zhang L, Wang Y, et al. Study of the Protective Effects of Dexamethasone on Multiple Organ Injury in Rats with Severe Acute Pancreatitis. JOP, 2007,8(4):400–412

    PubMed  Google Scholar 

  13. Gao YB, Wang XS, Liu W, et al. Effect of preventing cell Ca2+ overload on cytokines in severe acute pancreatitis. J Clin Res, 2007,24(7):1074–1075

    CAS  Google Scholar 

  14. Mayer K, Schaefer MB, Seeger W. Fish oil in the critically ill: from experimental to clinical data. Curr Opin Clin Nutr Metab Care, 2006,9(2):140–148

    Article  PubMed  CAS  Google Scholar 

  15. Nakamura K, Kariyazono H, Komokata T, et al. Influence of preoperative administration of ω-3 fatty acid-enriched supplement on inflammatory and immune responses in patients undergoing major surgery for cancer. Nutrition,2005,21(6):639–649

    Article  PubMed  CAS  Google Scholar 

  16. Heller AR, Rossler S, Litz RJ, et al. Omega-3 fatty acids improve the diagnosis-related clinical outcome. Crit Care Med, 2006,34(4):972–979

    Article  PubMed  CAS  Google Scholar 

  17. Stehr SN, Heller AR. Omega-3 fatty acid effects on biochemical indices following cancer surgery. Clin Chim Acta, 2006,373(1–2): 1–8.

    Article  PubMed  CAS  Google Scholar 

  18. Flint R, Windsor JA. Early Physiological Response to Intensive Care as a Clinically Relevant Approach to Predicting the Outcome in Severe Acute Pancreatitis. Arch Surg. 2004,139(4):438–443

    Article  PubMed  Google Scholar 

  19. Vasilescu C, Buttenschoen K, Olteanu M, et al. Severe acute pancreatitis between systematic inflammatory response syndrome and sepsis: insights from a mathematical model of endotoxin tolerance. Am J Surg, 2007,194:(4 Suppl): S33–S38

    Article  CAS  Google Scholar 

  20. Weiss G, Meyer F, Matthies B, et al. Immunomodulation by perioperative administration of n-3 fatty acids. Br J Nutr, 2002,87(Suppl 1): S89–S94

    Article  PubMed  CAS  Google Scholar 

  21. Tsekos E, Reuter C, Stehle P, et al. Perioperative administration of parenteral fish oil supplements in a routine clinical setting improves patient outcome after major abdominal surgery. Clin Nutr, 2004,23(3):325–330

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Jiongxin Xiong  (熊炯炘), Shikai Zhu  (朱世凯), Heshui Wu  (吴河水) & Chunyou Wang  (王春友)

  2. Department of Immunology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Yu Zhou  (周 玉)

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  1. Jiongxin Xiong  (熊炯炘)
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  2. Shikai Zhu  (朱世凯)
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  3. Yu Zhou  (周 玉)
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  4. Heshui Wu  (吴河水)
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  5. Chunyou Wang  (王春友)
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Correspondence to Jiongxin Xiong  (熊炯炘).

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Xiong, J., Zhu, S., Zhou, Y. et al. Regulation of ω-3 fish oil emulsion on the SIRS during the initial stage of severe acute pancreatitis. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 29, 35–38 (2009). https://doi.org/10.1007/s11596-009-0107-3

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  • DOI: https://doi.org/10.1007/s11596-009-0107-3

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