Abstract
The physically crosslinked poly(vinyl alcohol)/chitosan (CS) composite hydrogels were prepared by cyclic freezing/thawing techniques, and the microstructure and swelling behavior of the hydrogels in the simulated gastric (pH 1.0) and intestinal (pH 7.4) media were investigated. The experimental results of infrared spectra (IR), scanning electron microscope (SEM) and differential scanning calorimetry (DSC) demonstrated that poly(vinyl alcohol) and chitosan had good miscibility in the composite hydrogels, and the addition of chitosan perturbed the formation of poly(vinyl alcohol) crystallites. The swelling kinetics results indicated that the composite hydrogels had good pH sensitive properties to the acidic environments, and with the increase of chitosan content in the blend, the maximum swelling degreed and the swelling rate both increased, but it led to more dissolution at pH 1.0. And the composite hydrogels also exhibited good reversible swelling behavior with pH value of the swelling medium altering between 1.0 and 7.4. In addition, the higher freezing/thawing cycle times resulted in the lower swelling rate. Therefore, the swelling behavior of the composite hydrogels could be adjusted by changing the chitosan contents and the freezing/thawing cycle times.
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References
Cerchiara T, Luppi B, Bigucci F, et al. Substituted Polyvinylalcohol as a Drug Carrier for β-Carotene[J]. European Journal of Pharmaceutics and Biopharmaceutics, 2003, 56:401–405
Morita R, Honda R, Takahashi Y. Development of Oral Controlled Release Preparations, A PVA Swelling Controlled Released System (SCRS) I. Design of SCRS and Its Release Controlling Factor[J]. Journal of Controlled Release, 2000, 63:297–304
Hassan C M, Ward J H. Modeling of Crystal Dissolution of Poly(vinyl alcohol) Gels Produced by Freezing/Thawing Processes[J]. Polymer, 2000, 41:6729–6739
Huang G, Feng Y, He J, et al. Studies on Mechanical Properties of Cryo-Hydrogel[J]. Chemical Journal of Chinese Universities, 1991, 4:564–567 (in Chinese)
Hassan C M, Peppas N A. Structure and Morphology of Freeze/Thawed PVA Hydrogels[J]. Macromolecules, 2000, 33:2472–2479
Kim S Y, Lee Y M. Drug Release Behavior of Electrical Responsive Poly(vinyl alcohol)/Poly(acrylic acid) IPN Hydrogels under an Electric Stimulus[J]. Journal of Applied Polymer Science, 1999, 74:1752–1761
Park K R, Nho Y C. Preparation and Characterization by Radiation of Poly(vinyl alcohol) and Poly(N-vinylpyrrodidone) Hydrogels Containing Aloe Vera[J]. Journal of Applied Polymer Science, 2003, 90:1477–1485
Kim S J, Lee C K, Lee Y M, et al. Electrical/pH-Sensitive Swelling Behavior of Polyelectrolyte Hydrogels Prepared with Hyaluronic Acid-Poly(vinyl alcohol) Interpenetrating Polymer Networks[J]. Reactive & Functional Polymers, 2003, 55:291–298
Majeti N V, Ravi K. A Review of Chitin and Chitosan Applications[J]. Reactive & Functional Polymers, 2000, 46:1–27
Sinha V R, Singla A K, Wadhawan S, et al. Chitosan Microspheres as a Potential Carrier for Drugs[J]. International Journal of Pharmaceutics, 2004, 274:1–33
Qiu Y, Park K. Environment-sensitive Hydrogels for Drug Delivery[J]. Advanced Durg Delivery Review, 2001, 53:321–339
Liu M, Cheng R, Qian R, Investigation of Swelling Property of Poly(vinyl alcohol)Hydrogel[J]. Acta Polymerica Sinica, 1996, 2:234–239(in Chinese)
Guan Y L, Shao L, Yao K D. A Study on Correlation between Water State and Swelling Kinetics of Chitosan-Based Hydrogels[J]. Journal of Applied Polymer Science, 1996, 61:2325–2335
Zheng H, Du Y, Yu J. Preparation and Characterization of Chitosan/Poly(vinyl alcohol) Blend Fibers[J]. Journal of Applied Polymer Science, 2001, 80:2558–2565
Bajpai A K, Saini R. Preparation and Characterization of Biocompatible Spongy Cryogels of Poly(vinyl alcohol)-Gelatin and Study of Water Sorption Behaviour[J]. Polymer International, 2005, 54:1233–1242
Ricciardi R, Auriemma F, Rosa C D. Structure and Properties of Poly(vinyl alcohol) Hydrogels Obtained by Freeze/Thaw Techniques[J]. Macromolecular Symposia, 2005, 222:49–63
Bergera J, Reista M, Mayera J M, et al. Structure and Interactions in Chitosan Hydrogels Formed by Complexation or Aggregation for Biomedical Applications[J]. European Journal of Pharmaceutics and Biopharmaceutics, 2004, 57:35–52
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He, G., Zheng, H. & Xiong, F. Preparation and swelling behavior of physically crosslinked hydrogels composed of poly(vinyl alcohol) and chitosan. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 23, 816–820 (2008). https://doi.org/10.1007/s11595-007-6816-1
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DOI: https://doi.org/10.1007/s11595-007-6816-1