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Synthesis of graphene/carbon nanofiber for electrochemical determination of levodopa in the presence of uric acid

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Abstract

Carbon nanofiber (CNF) was prepared by electrospinning using polypropylene and nickel was coated on the CNF by electroless plating. Then, graphene (Gr) was synthesized on the surface of nickel by chemical vapor deposition. After etching nickel, the Gr/CNF was obtained eventually and then used as a working electrode for the determination of levodopa in the presence of uric acid by cyclic voltammetry and differential pulse voltammetry. The morphology and structure were investigated by scanning electron microscopy and Raman spectroscopy, respectively. The results indicate that the electrode exhibits a high sensitivity of 0.26 μA·μM−1 and a low measured limit of detection of 1 μM for levodopa in the range of 1–60 μM. The electrode shows excellent selectivity, reproducibility, and stability. It was also applied to determine levodopa in the spiked human urine samples.

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Funding

This work is supported by the Natural Science Foundation of Heilongjiang Province (LC2015020), Technology Foundation for Selected Overseas Chinese Scholar, Ministry of Personnel of China (2015192), the Innovative Talent Fund of Harbin city (2016RAQXJ185), and Science Funds for the Young Innovative Talents of HUST (201604).

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Authors and Affiliations

  1. School of Materials Science and Engineering, Harbin University of Science and Technology, Harbin, 150040, People’s Republic of China

    Wan Qiu Wang, Hong Yan Yue, Ze Min Yu, Shuo Huang, Shan Shan Song, Xin Gao, En Hao Guan, Hong Jie Zhang & Zhao Wang

  2. Department of Neurology, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, People’s Republic of China

    Shuo Huang

Authors
  1. Wan Qiu Wang
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  2. Hong Yan Yue
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  3. Ze Min Yu
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  4. Shuo Huang
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  5. Shan Shan Song
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  6. Xin Gao
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  7. En Hao Guan
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  8. Hong Jie Zhang
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  9. Zhao Wang
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Correspondence to Hong Yan Yue.

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Highlights

1. Nickel is coated on the carbon nanofiber (CNF) by electroless nickel plating.

2. Graphene (Gr) was grown on the surface of nickel by chemical vapor deposition.

3. The Gr/CNF shows a high sensitivity of 0.26 μA·μM−1 for determination of levodopa.

4. The Gr/CNF also shows a low measured limit of detection, excellent selectivity and stability.

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Wang, W.Q., Yue, H.Y., Yu, Z.M. et al. Synthesis of graphene/carbon nanofiber for electrochemical determination of levodopa in the presence of uric acid. Ionics 25, 2835–2843 (2019). https://doi.org/10.1007/s11581-018-2801-2

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  • DOI: https://doi.org/10.1007/s11581-018-2801-2

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