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A sensitive amperometric detection of dopamine agonist drug pramipexole at functionalized multi-walled carbon nanotubes (f-MWCNTs) modified electrode

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Abstract

The electrochemical detection of dopaminergic agonist drug pramipexole dihydrochloride monohydrate (PPX) has been investigated by cyclic voltammetric (CV) and amperometric i–t techniques at functionalized multi-walled carbon nanotubes-modified glassy carbon electrode. For the first time, a sensitive and rapid electrochemical method was developed for the determination of PPX. The surface morphological characteristics of the proposed electrode have been studied by using transmission electron microscopy (TEM); further, electrochemical impedance spectroscopy (EIS) and Fourier transform infrared spectroscopy (FTIR) have been employed. PPX shows an irreversible anodic peak, which may be ascribed to the oxidation of the –NH groups of PPX. The proposed method was showing good sensitivity of 0.993 μA μM−1 cm−2 with a linear range of 5 to 340 μM by amperometric i–t and CV technique shows a linear range of 12.5 to 313 μM with a sensitivity of 1.92 μA μM−1 cm−2. The recovery of PPX from blood serum samples was found 100.6 and 98.9 %, respectively. Furthermore, the proposed method has been demonstrated for the determination of PPX in commercially available pharmaceutical samples and good agreement of results obtained.

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Acknowledgments

This work was supported by the National Science Council and the Ministry of Education of Taiwan (Republic of China).

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Authors and Affiliations

  1. Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan, Republic of China

    Srikanth Cheemalapati, Chelladurai Karuppiah & Shen-Ming Chen

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  1. Srikanth Cheemalapati
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  2. Chelladurai Karuppiah
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  3. Shen-Ming Chen
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Correspondence to Shen-Ming Chen.

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Cheemalapati, S., Karuppiah, C. & Chen, SM. A sensitive amperometric detection of dopamine agonist drug pramipexole at functionalized multi-walled carbon nanotubes (f-MWCNTs) modified electrode. Ionics 20, 1599–1606 (2014). https://doi.org/10.1007/s11581-014-1123-2

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  • DOI: https://doi.org/10.1007/s11581-014-1123-2

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