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Detecting prostate cancer using deep learning convolution neural network with transfer learning approach

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Abstract

Prostate Cancer in men has become one of the most diagnosed cancer and also one of the leading causes of death in United States of America. Radiologists cannot detect prostate cancer properly because of complexity in masses. In recent past, many prostate cancer detection techniques were developed but these could not diagnose cancer efficiently. In this research work, robust deep learning convolutional neural network (CNN) is employed, using transfer learning approach. Results are compared with various machine learning strategies (Decision Tree, SVM different kernels, Bayes). Cancer MRI database are used to train GoogleNet model and to train Machine Learning classifiers, various features such as Morphological, Entropy based, Texture, SIFT (Scale Invariant Feature Transform), and Elliptic Fourier Descriptors are extracted. For the purpose of performance evaluation, various performance measures such as specificity, sensitivity, Positive predictive value, negative predictive value, false positive rate and receive operating curve are calculated. The maximum performance was found with CNN model (GoogleNet), using Transfer learning approach. We have obtained reasonably good results with various Machine Learning Classifiers such as Decision Tree, Support Vector Machine RBF kernel and Bayes, however outstanding results were obtained by using deep learning technique.

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References

  • Akin O, Sala E, Moskowitz CS, Kuroiwa K, Ishill NM, Pucar D, Scardino PT, Hricak H (2006) Transition zone prostate cancers: features, detection, localization, and staging at endorectal MR imaging. Radiology 239:784–792

    PubMed  Google Scholar 

  • Asvadi NH, Afshari Mirak S, Mohammadian Bajgiran A, Khoshnoodi P, Wibulpolprasert P, Margolis D, Sisk A, Reiter RE, Raman SS (2018) 3T multiparametric MR imaging, PIRADSv2-based detection of index prostate cancer lesions in the transition zone and the peripheral zone using whole mount histopathology as reference standard. Abdom Radiol 43:3117–3124

    Google Scholar 

  • Bengio Y (2013) Deep learning of representations: looking forward. In: Lecture notes in computer science (including its subseries lecture notes in artificial intelligence and lecture notes in bioinformatics), 7978 LNAI, pp 1–37

  • Bengio Y, Courville AC, Vincent P (2012) Unsupervised feature learning and deep learning: A review and new perspectives. CoRR. arxiv:1206.5538

  • Bonzon P (2017) Towards neuro-inspired symbolic models of cognition: linking neural dynamics to behaviors through asynchronous communications. Cogn Neurodyn 11:327–353

    PubMed  PubMed Central  Google Scholar 

  • Cameron A, Modhafar A, Khalvati F, Lui D, Shafiee MJ, Wong A, Haider M (2014) Multiparametric MRI prostate cancer analysis via a hybrid morphological-textural model. In: Conference proceedings: annual international conference of the IEEE engineering in medicine and biology society. IEEE engineering in medicine and biology society. Conference 2014, pp 3357–3360

  • Chen W, Zheng R, Baade PD, Zhang S, Zeng H, Bray F, Jemal A, Yu XQ, He J (2016) Cancer statistics in China. CA Cancer J Clin 66:115–132

    PubMed  Google Scholar 

  • Chesnais AL, Niaf E, Bratan F, Mège-Lechevallier F, Roche S, Rabilloud M, Colombel M, Rouvière O (2013) Differentiation of transitional zone prostate cancer from benign hyperplasia nodules: evaluation of discriminant criteria at multiparametric MRI. Clin Radiol 68:e323–e330

    CAS  PubMed  Google Scholar 

  • Chou R, Croswell JM, Dana T, Bougatsos C, Blazina I, Fu R (2011) Review annals of internal medicine screening for prostate cancer: a review of the evidence for the U.S. preventive services task force. Ann Intern Med 155:375–386

    PubMed  Google Scholar 

  • Costa DN, Pedrosa I, Donato F, Roehrborn CG, Rofsky NM (2015) MR imaging-transrectal US fusion for targeted prostate biopsies: implications for diagnosis and clinical management. RadioGraphics 35:696–708

    PubMed  Google Scholar 

  • Doyle S, Madabhushi A, Feldman M, Tomaszeweski J (2006) A boosting cascade for automated detection of prostate cancer from digitized histology. In: Medical image computing and computer-assisted intervention—MICCAI 2006, Pt 2 4191, pp 504–511

  • Eggener SE, Badani K, Barocas DA et al (2015) Gleason 6 prostate cancer: translating biology into population health. J Urol 194:626–634

    PubMed  PubMed Central  Google Scholar 

  • Eigen D, Puhrsch C, Fergus R (2014) Depth map prediction from a single image using a multi-scale deep network. In: NIPS, pp 1–9

  • Fan Y, Shen D, Gur RC, Gur RE, Davatzikos C (2007) COMPARE: classification of morphological patterns using adaptive regional elements. IEEE Trans Med Imaging 26:93–105

    PubMed  Google Scholar 

  • Girshick R, Donahue J, Darrell T, Berkeley UC, Malik J (2012) Girshick_Rich_Feature_Hierarchies_2014_CVPR_paper.pdf. 2–9

  • Goodfellow I, Bengio Y, Courville A (2016) Deep learning. Nature 521:800

    Google Scholar 

  • Gutstein S, Fuentes O, Freudenthal E (2008) Knowledge transfer in deep convolutional neural nets. Int J Artif Intell Tools 17:555–567

    Google Scholar 

  • Hajian-Tilaki K (2013) Receiver operating characteristic (ROC) curve analysis for medical diagnostic test evaluation. Casp J Intern Med 4:627–635

    Google Scholar 

  • Han SM, Lee HJ, Choi JY (2008) Computer-aided prostate cancer detection using texture features and clinical features in ultrasound image. J Digit Imaging 21:121–133

    PubMed Central  Google Scholar 

  • He K, Zhang X, Ren S, Sun J (2016) Deep residual learning for image recognition, pp 770–778

  • Hinton GE, Osindero S, Teh Y-W (2006) Communicated by Yann Le Cun A Fast learning algorithm for deep belief nets 500 units 500 units. Neural Comput 18:1527–1554

    PubMed  Google Scholar 

  • Hinton G, Deng L, Yu D et al (2012) Deep neural networks for acoustic modeling in speech recognition: the shared views of four research groups. IEEE Signal Process Mag 29:82–97

    Google Scholar 

  • Homma T, Atlas L, Marks RJ II (1988) An artificial neural network for spatio-temporal bipolar patters: application to phoneme classification. Adv Neural Inf Process Syst 1(1):31–40

    Google Scholar 

  • Hricak H, Choyke PL, Eberhardt SC, Leibel S, Scardino PT (2007) Imaging prostate cancer: a multidisciplinary perspective 1. Radiology 243:28–53

    PubMed  Google Scholar 

  • Hussain L (2018) Detecting epileptic seizure with different feature extracting strategies using robust machine learning classification techniques by applying advance parameter optimization approach. Cogn Neurodyn 12:271–294

    PubMed  PubMed Central  Google Scholar 

  • Hussain L, Aziz W, Alowibdi JSJSJS, Habib N, Rafique M, Saeed S, Kazmi SZHSZ (2017) Symbolic time series analysis of electroencephalographic (EEG) epileptic seizure and brain dynamics with eye-open and eye-closed subjects during resting states. J Physiol Anthropol 36:21

    PubMed  PubMed Central  Google Scholar 

  • Hussain L, Ahmed A, Saeed S, Rathore S, Awan IA, Shah SA, Majid A, Idris A, Awan AA (2018a) Prostate cancer detection using machine learning techniques by employing combination of features extracting strategies. Cancer Biomark 21:393–413

    PubMed  Google Scholar 

  • Hussain L, Saeed S, Awan IA, Idris A, Nadeem MSAA, Chaudhary Q-A, Chaudhry Q-A (2018b) Detecting brain tumor using machine learning techniques based on different features extracting strategies. Curr Med Imaging Former Curr Med Imaging Rev 14:595–606

    Google Scholar 

  • Hussain L, Ali A, Rathore S, Saeed S, Idris A, Usman MU, Iftikhar MA, Suh DY (2018c) Applying bayesian network approach to determine the association between morphological features extracted from prostate cancer images. IEEE Access 7:1586–1601

    Google Scholar 

  • Hussain L, Aziz W, Alshdadi AA, Ahmed Nadeem MS, Khan IR, Chaudhry Q-U-A (2019) Analyzing the dynamics of lung cancer imaging data using refined fuzzy entropy methods by extracting different features. IEEE Access 7:64704–64721

    Google Scholar 

  • Isselmou AEK, Zhang S, Xu G (2016) A novel approach for brain tumor detection using MRI images. J Biomed Sci Eng 09:44–52

    Google Scholar 

  • Karpathy A, Li FF (2015) Deep visual-semantic alignments for generating image descriptions. In: Proceedings of the IEEE computer society conference on computer vision and pattern recognition, pp 3128–3137

  • Karpathy A, Toderici G, Shetty S, Leung T, Sukthankar R, Fei-Fei L (2014) Large-scale video classification with convolutional neural networks. In: IEEE conference on computer vision and pattern recognition (CVPR), 2014, pp 1725–1732

  • Kattan MW, Potters L, Blasko JC, Beyer DC, Fearn P, Cavanagh W, Leibel S, Scardino PT (2001) CME article brachytherapy in prostate cancer. Urology 4295:393–399

    Google Scholar 

  • Khaki-Khatibi F, Nourazarian A, Ahmadi F, Farhoudi M, Savadi-Oskouei D, Pourostadi M, Asgharzadeh M (2019) Relationship between the use of electronic devices and susceptibility to multiple sclerosis. Cogn Neurodyn 13:287–292

    PubMed  PubMed Central  Google Scholar 

  • Krizhevsky A, Sutskever I, Hinton GE (2012) ImageNet classification with deep convolutional neural networks. Adv Neural Inf Process Syst 1097–1105

  • LeCun Y, Bottou L, Bengio Y, Haffner P (1998) Gradient-based learning applied to document recognition. Proc IEEE. https://doi.org/10.1109/5.726791

    Article  Google Scholar 

  • Lemaitre L, Puech P, Poncelet E, Bouyé S, Leroy X, Biserte J, Villers A (2009) Dynamic contrast-enhanced MRI of anterior prostate cancer: morphometric assessment and correlation with radical prostatectomy findings. Eur Radiol 19:470–480

    PubMed  Google Scholar 

  • Li J, Weng Z, Xu H, Zhang Z, Miao H, Chen W, Liu Z (2018) Support Vector Machines (SVM) classification of prostate cancer Gleason score in central gland using multiparametric magnetic resonance images: a cross-validated study. Eur J Radiol 98:61–67

    PubMed  Google Scholar 

  • Lillicrap TP, Hunt JJ, Pritzel A, Heess N, Erez T, Tassa Y, Silver D, Wierstra D (2015) Continuous control with deep reinforcement learning. Clin Linguist Phon. https://doi.org/10.1561/2200000006

    Article  Google Scholar 

  • Liu S, Liu S, Cai W, Pujol S, Kikinis R, Feng D (2014) Early diagnosis of Alzheimer’s disease with deep learning. In: 2014 IEEE 11th international symposium on biomedical imaging. IEEE, pp 1015–1018

  • Liu Y, Yang G, Mirak SA, Hosseiny M, Azadikhah A, Zhong X, Reiter RE, Lee Y, Raman SS, Sung K (2019) Automatic prostate zonal segmentation using fully convolutional network with feature pyramid attention. IEEE Access 7:163626–163632

    Google Scholar 

  • Mooij G, Bagulho I, Huisman H (2018) Automatic segmentation of prostate zones

  • Oto A, Kayhan A, Jiang Y, Tretiakova M, Yang C, Antic T, Dahi F, Shalhav AL, Karczmar G, Stadler WM (2010) Prostate cancer: differentiation of central gland cancer from benign prostatic hyperplasia by using diffusion-weighted and dynamic contrast-enhanced MR imaging. Radiology 257:715–723

    PubMed  Google Scholar 

  • Perez IM, Toivonen J, Movahedi P, Kiviniemi A, Pahikkala T, Aronen HJ, Jambor I (2016) Diffusion weighted imaging of prostate cancer: prediction of cancer using texture features from the parametric maps of the monoexponential and kurtosis functions using a grid approach. 0–7

  • Pinto A, Alves V, Silva CA (2016) Brain tumor segmentation using convolutional neural networks in MRI images. IEEE Trans Med Imaging 35:1240–1251

    PubMed  Google Scholar 

  • Prostate MR (2018) Image database. http://prostatemrimagedatabase.com/index.html. Accessed 11 Mar 2018

  • Rathore S, Hussain M, Khan A (2015) Automated colon cancer detection using hybrid of novel geometric features and some traditional features. Comput Biol Med 65:279–296

    PubMed  Google Scholar 

  • Ronneberger O, Fischer P, Brox T (2015) U-net: convolutional networks for biomedical image segmentation. In: Lecture notes in computer science (including its subseries lecture notes in artificial intelligence and lecture notes in bioinformatic). Springer, pp 234–241

  • Schröder FH, Hugosson J, Roobol MJ et al (2009) Screening and prostate-cancer mortality in a randomized european study. N Engl J Med 360:1320–1328

    PubMed  Google Scholar 

  • Seltzer SE, Getty DJ, Tempany CM, Pickett RM, Schnall MD, McNeil BJ, Swets JA (1997) Staging prostate cancer with MR imaging: a combined radiologist-computer system. Radiology 202:219–226

    CAS  PubMed  Google Scholar 

  • Shelhamer E, Long J, Darrell T (2017) Fully convolutional networks for semantic segmentation. IEEE Trans Pattern Anal Mach Intell 39:640–651

    PubMed  Google Scholar 

  • Siegel RL, Miller KD, Fedewa SA, Ahnen DJ, Meester RGS, Barzi A, Jemal A (2017) Colorectal cancer statistics, 2017. CA Cancer J Clin 67:177–193

    PubMed  Google Scholar 

  • Szegedy C, Liu W, Jia Y, Sermanet P, Reed S, Anguelov D, Erhan D, Vanhoucke V, Rabinovich A (2015) Going deeper with convolutions, pp 1–9

  • Taigman Y, Yang M, Ranzato M, Wolf L (2014) DeepFace: closing the gap to human-level performance in face verification. In: Proccedings of the computer society conference on computer vision and pattern recognition, pp 1701–1708

  • Talcott JA, Manola J, Chen RC, Clark JA, Kaplan I, D’Amico AV, Zietman AL (2014) Using patient-reported outcomes to assess and improve prostate cancer brachytherapy. BJU Int 114:511–516

    PubMed  Google Scholar 

  • Vos PC, Hambrock T, Barenstz JO, Huisman HJ (2010) Computer-assisted analysis of peripheral zone prostate lesions using T2-weighted and dynamic contrast enhanced T1-weighted MRI. Phys Med Biol 55:1719–1734

    PubMed  Google Scholar 

  • Wall WA, Wiechert L, Comerford A, Rausch S (2010) Towards a comprehensive computationalmodel for the respiratory system. Int J Numer Methods Biomed Eng 26:807–827

    Google Scholar 

  • Yu KK, Hricak H (2000) Imaging prostate cancer. J Urol 38:59–85

    Google Scholar 

  • Zabihollahy F, Schieda N, Krishna Jeyaraj S, Ukwatta E (2019) Automated segmentation of prostate zonal anatomy on T2-weighted (T2W) and apparent diffusion coefficient (ADC) map MR images using U-Nets. Med Phys 46:3078–3090

    PubMed  Google Scholar 

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Correspondence to Lal Hussain.

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Abbasi, A.A., Hussain, L., Awan, I.A. et al. Detecting prostate cancer using deep learning convolution neural network with transfer learning approach. Cogn Neurodyn 14, 523–533 (2020). https://doi.org/10.1007/s11571-020-09587-5

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