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Treatment of a segmental defect in open radial and ulnar shaft fractures using rhBMP-2 and iliac crest bone graft: a case report

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References

  1. Bax BE, Wozney JM, Ashhurst DE. Bone morphogenetic protein-2 increases the rate of callus formation after fracture of the rabbit tibia. Calcif Tissue Int. 1999;65:83–9.

    Article  PubMed  CAS  Google Scholar 

  2. Bostrom M, Lane JM, Tomin E, et al. Use of bone morphogenetic protein-2 in the rabbit ulnar nonunion model. Clin Orthop. 1996;327:272–82.

    Article  PubMed  Google Scholar 

  3. Bouxsein ML, Turek TJ, Blake CA, et al. Recombinant human bone morphogenetic protein-2 accelerates healing in a rabbit ulnar osteotomy model. J Bone Joint Surg. 2001;83:1219–30.

    PubMed  Google Scholar 

  4. Boyne PJ. Application of bone morphogenetic proteins in the treatment of clinical oral and maxillofacial osseous defects. J Bone Joint Surg. 2001;83:146–50.

    Google Scholar 

  5. Boyne PJ, Lilly LC, Marx RE, et al. De novo bone induction by recombinant human bone morphogenetic protein-2 (rhBMP-2) in maxillary sinus floor augmentation. J Oral Maxillofac Surg. 2005;63:1693–707.

    Article  PubMed  Google Scholar 

  6. Boyne PJ, Marx RE, Nevins M, et al. A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation. Int J Periodontics Restorative Dent. 1997;17(1):11–25.

    PubMed  CAS  Google Scholar 

  7. Burkus JK, Sandhu HS, Gornet MF, et al. Use of rhBMP-2 in combination with structural cortical allografts: clinical and radiographic outcomes in anterior lumbar spinal surgery. J Bone Joint Surg. 2005;87(6):1205–12.

    Article  PubMed  Google Scholar 

  8. Cook SD, Salkeld SL, Brinker MR, et al. Use of an osteoinductive biomaterial (RhOP-1) in healing large segmental bone defects. J Orthop Trauma. 1998;12:407–12.

    Article  PubMed  CAS  Google Scholar 

  9. DeCoster TA, Gehlert RJ, Mikola EA, et al. Management of posttraumatic segmental bone defects. JAAOS. 2004;12:28–38.

    Google Scholar 

  10. Edwards 3rd RB, Seeherman HJ, Bogdanske JJ, et al. Percutaneous injection of recombinant human bone morphogenetic protein-2 in a calcium phosphate paste accelerates healing of a canine tibial osteotomy. J Bone Joint Surg. 2004;86:1425–38.

    PubMed  Google Scholar 

  11. Glassman SD, Carreon L, Djurasovic M, et al. Posterolateral lumbar spine fusion with INFUSE bone graft. Spine. 2007;J 7(1):44–9. PMID: 17197332.

    Google Scholar 

  12. Govender S, Csimma C, Genant HK, et al. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. BMP-2 Evaluation in Surgery for Tibial Trauma (BESTT) Study Group. J Bone Joint Surg. 2002;84-A:2123–34. PMID: 12473698.

    PubMed  Google Scholar 

  13. Haid Jr RW, Branch Jr CL, Alexander JT, et al. Posterior lumbar interbody fusion using recombinant human bone morphogenetic protein type 2 with cylindrical interbody cages. Spine. 2004;J 4(5):527–38. PMID: 15363423.

    Google Scholar 

  14. Johnson EE, Urist MR. Human bone morphogenetic protein allografting for reconstruction of femoral nonunion. Clin Orthop. 2000;371:61–74.

    Article  PubMed  Google Scholar 

  15. Jones AL, Bucholz RW, Bosse MJ, et al. A Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects: a randomized, controlled trial. J Bone Joint Surg. 2006;88(7):1431–41.

    Article  PubMed  Google Scholar 

  16. McKay B, Sandhu HS. Use of recombinant human bone morphogenetic protein-2 in spinal fusion applications. Spine. 2002;27:S66–85.

    Article  PubMed  Google Scholar 

  17. Moroni A, Rollo G, Guzzardella M, et al. Surgical treatment of isolated forearm non-union with segmental bone loss. Injury. 1997;28(8):497–504.

    Article  PubMed  CAS  Google Scholar 

  18. Nauth A, Ristiniemi J, McKee MD, et al. Bone morphogenetic proteins in open fractures: past, present, and future. Injury. 2009;40 Suppl 3:S27–31.

    Article  PubMed  Google Scholar 

  19. Reddi AH. Initiation of fracture repair by bone morphogenetic proteins. Clin Orthop Relat Res. 1998;355S:s66–72.

    Article  Google Scholar 

  20. Riew KD, Wright NM, Cheng S, et al. Induction of bone formation using a recombinant adenoviral vector carrying the human BMP-2 gene in a rabbit spinal fusion model. Calcif Tissue Int. 1998;63:357–60.

    Article  PubMed  CAS  Google Scholar 

  21. Ring D, Allende C, Jafarnia K, et al. Ununited diaphyseal forearm fractures with segmental defects: plate fixation and autogenous cancellous bone-grafting. J Bone Joint Surg. 2004;86:2440–5.

    PubMed  Google Scholar 

  22. Schwartz ND, Hicks BM. Eight-centimeter segmental ulnar defect treated with recombinant human bone orphogenetic protein-2. Am J Orthop (Belle Mead NJ). 2008;37(11):569–71.

    Google Scholar 

  23. Sciadini MF, Johnson KD. Evaluation of recombinant human bone morphogenetic protein-2 as a bone-graft substitute in a canine segmental defect model. J Orthop Res. 2000;18(2):289–302.

    Article  PubMed  CAS  Google Scholar 

  24. Swiontkowski MF, Aro HT, Donell S, et al. Recombinant human bone morphogenetic protein-2 in open tibial fractures. A subgroup analysis of data combined from two prospective randomized studies. J Bone Joint Surg. 2006;88(6):1258–65.

    Article  PubMed  Google Scholar 

  25. Urist MR, Silverman BF, Buring K, et al. The bone induction principle. Clin Orthop Relat Res. 1967;53:243–83.

    Article  PubMed  CAS  Google Scholar 

  26. Valentin-Opran A, Wozney J, Csimma C, et al. Clinical evaluation of recombinant human bone morphogenetic protein-2. Clin Orthop. 2002;395:110–20.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Division of Hand and Microvascular Surgery, Department of Orthopaedics, UMDNJ-New Jersey Medical School, 90 Bergen Street, DOC 1200, Newark, NJ, 07103, USA

    John T. Capo, Matthew S. Marcus & Ben Shamian

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  1. John T. Capo
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  2. Matthew S. Marcus
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  3. Ben Shamian
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Correspondence to John T. Capo.

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Capo, J.T., Marcus, M.S. & Shamian, B. Treatment of a segmental defect in open radial and ulnar shaft fractures using rhBMP-2 and iliac crest bone graft: a case report. HAND 6, 424–428 (2011). https://doi.org/10.1007/s11552-011-9348-2

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