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Performance evaluation of a C-Arm CT perfusion phantom

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International Journal of Computer Assisted Radiology and Surgery Aims and scope Submit manuscript

Abstract

Purpose Brain perfusion measurement in stroke patients provides important information on the infarct area and state of involved tissue. Interventional C-Arm angiography systems can provide perfusion measurements. A CT perfusion phantom was developed for C-Arm perfusion imaging to test and evaluate this method and to aid in the design and validation of scan protocols.

Methods A phantom test device was designed based on the anatomy of the human head. Four feeding arteries divided into sixteen sub-branches that lead into a sintered board simulating brain parenchyma. Perfusion measurements were performed using two conventional clinical CT scanners as the gold standard and with a C-Arm CT system to test and compare the implementations. The phantom’s input parameters, contrast medium and flow properties were varied. A cerebral perfusion deficit was simulated by occlusion of a feeding artery tube.

Results CT perfusion maps of the sintered board brain tissue surrogate were computed and qualitatively compared for both conventional CT and C-Arm CT systems. A characteristic flow pattern of the tissue board was identifiable in both modalities. The characteristic flow pattern of the resulting perfusion maps is reproducible. The calculated flow and volume were directly related.

Conclusions A new CT perfusion phantom was developed and tested. This phantom is an appropriate model for CT-based tissue perfusion measurements in both conventional CT scanners and C-Arm CT scanners. The influence of input parameter changes can be visualized. Perfusion deficits after occlusion of a feeding artery are readily simulated and identified with CT.

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Acknowledgments

The authors would like to thank their colleagues at the chair for Healthcare Telematics and Medical Engineering and the department of Neuroradiology at the Otto-von-Guericke University of Magdeburg. This research was financially supported by the Federal Ministry of Education and Research (BMBF) in context of the ’INKA’ project and Siemens AG, Healthcare Sector, Germany.

Conflict of interest

Axel Boese, Sebastian Gugel, Steffen Serowy, Jonas Purmann, Georg Rose, Oliver Beuing, Martin Skalej, Research Support (including provision of equipment and materials): Siemens AG, Healthcare Sector, Forchheim, Germany, Details: The manufacturer provided sponsored research funding through channels approved by Otto-von-Guericke University. The manufacturer provided equipment for this study and donated all costs associated with the animal study. Yiannis Kyriakou, Other Financial Relationships: Siemens AG, Healthcare Sector, Details: Employee. Yu Deuerling-Zheng, Other Financial Relationships: Siemens AG, Healthcare Sector, Details: Employee.

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Authors and Affiliations

  1. Chair for Healthcare Telematics and Medical Engineering, Otto-von-Guericke University, Magdeburg, Germany

    Axel Boese, Sebastian Gugel, Steffen Serowy, Jonas Purmann & Georg Rose

  2. Department of Neuroradiology, Otto-von-Guericke University, Magdeburg, Germany

    Oliver Beuing & Martin Skalej

  3. Siemens AG, Healthcare Sector, Forchheim, Germany

    Yiannis Kyriakou & Yu Deuerling-Zheng

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  1. Axel Boese
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  2. Sebastian Gugel
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  3. Steffen Serowy
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  4. Jonas Purmann
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  5. Georg Rose
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  6. Oliver Beuing
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  7. Martin Skalej
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  8. Yiannis Kyriakou
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  9. Yu Deuerling-Zheng
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Correspondence to Axel Boese.

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Boese, A., Gugel, S., Serowy, S. et al. Performance evaluation of a C-Arm CT perfusion phantom. Int J CARS 8, 799–807 (2013). https://doi.org/10.1007/s11548-012-0804-4

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  • DOI: https://doi.org/10.1007/s11548-012-0804-4

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