Skip to main content

Advertisement

Log in

Protecting sensitive patient groups from imaging using ionizing radiation: effects during pregnancy, in fetal life and childhood

  • COMPUTED TOMOGRAPHY
  • Published:
La radiologia medica Aims and scope Submit manuscript

Abstract

The frequency of imaging examinations requiring radiation exposure in children (especially CT) is rapidly increasing. This paper reviews the current evidence in radiation protection in pediatric imaging, focusing on the recent knowledge of the biological risk related to low doses exposure. Even if there are no strictly defined limits for patient radiation exposure, it is recommended to try to keep doses as low as reasonably achievable (the ALARA principle). To achieve ALARA, several techniques to reduce the radiation dose in radiation-sensitive patients groups are reviewed. The most recent recommendations that provide guidance regarding imaging of pregnant women are also summarized, and the risk depending on dose and phase of pregnancy is reported. Finally, the risk-benefit analysis of each examination, and careful communication of this risk to the patient, is emphasized.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. EC. COUNCIL DIRECTIVE 2013/59/EURATOM of 5 December 2013 laying down basic safety standards for protection against the dangers arising from exposure to ionising radiation, and repealing Directives 89/618/Euratom, 90/641/Euratom, 96/29/Euratom, 97/43/Euratom and 2003/122/Euratom. https://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=OJ:L:2014:013:0001:0073:EN:PDF. Accessed 29 Jan 2019

  2. Hall EJ, Giaccia AJ (2006) Radiobiology for the radiologist, 6th edn. Lippincott, Williams and Wilkins, Philadelphia

    Google Scholar 

  3. Little JB et al (2003) Ionizing radiation. In: Kufe DW, Pollock RE, Weichselbaum RR (eds) Holland-Frei cancer medicine, 6th edn. Decker, Ontario

    Google Scholar 

  4. International Commission on Radiological Protection. Statement on tissue reactions. http://www.icrp.org/docs/ICRP%20Statement%20on%20Tissue%20Reactions.pdf. Accessed 29 Jan 2019

  5. McCollough CH, Schueler BA, Atwell TD et al (2007) Radiation exposure and pregnancy: when should we be concerned? Radiographics 7:909–917

    Article  Google Scholar 

  6. Brenner DJ, Elliston CD, Hall EJ, et al. Estimated risks of radiation-induced fatal cancer from pediatric CT. AJR Am J Roentgenol

  7. Shuryak I, Sachs RK, Brenner DJ (2010) Cancer risks after radiation exposure in middle age. J Natl Cancer Inst 102:1–9

    Article  CAS  Google Scholar 

  8. Radiation Effects Research Foundation. Hiroshima, Japan. http://www.rerf.or.jp/library/dl_e/index.html. Accessed 10 Dec 2011. [Accessed 29 Jan 2019]

  9. National Research Council. Health risks from exposure to low levels of ionizing radiation:BEIR VII—phase 2 (2006) Committee to Assess Health Risks from Exposure to Low Levels of Ionizing Radiation. National Academies Press, Washington, DC

  10. Ulsh BA (2010) Checking the foundation: recent radiobiology and the linear no-threshold theory. Health Phys 99:747–758

    Article  CAS  PubMed  Google Scholar 

  11. Scott BR (2008) Low-dose radiation risk extrapolation fallacy associated with the linear no-threshold model. Hum Exp Toxicol 27(2):163–168

    Article  PubMed  Google Scholar 

  12. Hall EJ (2009) Radiation biology for pediatric radiologists. Pediatr Radiol 39(1):S57–S64

    Article  PubMed  Google Scholar 

  13. Ozasa K, Shimizu Y, Suyama A, Kasagi F, Soda M, Grant EJ, Sakata R, Sugiyama H, Kodama K (2012) Studies of the mortality of atomic bomb survivors, report 14, 1950–2003: an overview of cancer and noncancer diseases. Radiat Res 177:229–243

    Article  CAS  PubMed  Google Scholar 

  14. Grant EJ, Brenner A, Sugiyama H, Sakata R, Sadakane A, Utada M, Cahoon EK, Milder CM, Soda M, Cullings HM, Preston DL, Mabuchi K, Ozasa K (2017) Solid cancer incidence among the life span study of atomic bomb survivors: 1958–2009. Radiat Res 187(5):513–537. https://doi.org/10.1667/rr14492.1

    Article  CAS  PubMed  Google Scholar 

  15. Bauer AJ, Davies L (2018) Why the data from the fukushima health management survey after the daiichi nuclear power station accident are important. JAMA Otolaryngol Head Neck Surg 145:11–13

    Article  Google Scholar 

  16. Bernier MO, Baysson H, Pearce MS et al (2018) Cohort profile: the EPI-CT study: a European pooled epidemiological study to quantify the risk of radiation-induced cancer from paediatric CT. Int J Epidemiol. https://doi.org/10.1093/ije/dyy231

    Article  Google Scholar 

  17. https://www.aapm.org/org/policies/details.asp?id=439&type=PP. Accessed 29 Jan 2019

  18. Toma P, Cannata V, Genovese E, Magistrelli A, Granata C (2017) Radiation exposure in diagnostic imaging: wisdom and prudence, but still a lot to understand. Radiol Med 122(3):215–220

    Article  PubMed  Google Scholar 

  19. Imaida K, Hasegawa R, Kato T, Futakuchi M, Takahashi S, Ogawa K, Asamoto M, Yamamoto T, Suzuki K, Inagaki T, Shinagawa N, Shirai T (1997) Clinico-pathological analysis on cancers of autopsy cases in a geriatric hospital. Pathol Int 47:293–300

    Article  CAS  PubMed  Google Scholar 

  20. https://ec.europa.eu/energy/en/topics/nuclear-energy/radiation-protection/scientific-seminars-and-publications/radiation-protection-publications. Accessed 29 Jan 2019

  21. https://www.iaea.org/resources/rpop/health-professionals/radiology/diagnostic-reference-levels/diagnostic-reference-levels-in-paediatric-radiology. Accessed 29 Jan 2019

  22. http://www.eurosafeimaging.org/wp/wp-content/ uploads/2015/09/European-Guidelines-on-DRLs-for-Paediatric- Imaging_FINAL-for-workshop_30-Sept-2015.pdf. [Accessed 29 Jan 2019]

  23. https://ec.europa.eu/energy/sites/ener/files/rp_185.pdf. Accessed 29 Jan 2019

  24. www.imagegently.org. Accessed 29 Jan 2019

  25. www.eurosafeimaging.org. Accessed 29 Jan 2019

  26. Kaplan SL, Magill D, Felice MA, Xiao R, Ali S, Zhu X (2018) Female gonadal shielding with automatic exposure control increases radiation risks. Pediatr Radiol 48(2):227–234

    Article  PubMed  Google Scholar 

  27. Lee MC, Lloyd J, Solomito MJ (2017) Poor utility of gonadal shielding for pediatric pelvic radiographs. Orthopedics 40(4):e623–e627

    Article  PubMed  Google Scholar 

  28. Frantzen MJ, Robben S, Postma AA, Zoetelief J, Wildberger JE, Kemerink GJ (2012) Gonad shielding in paediatric pelvic radiography: disadvantages prevail over benefit. Insights Imaging 3(1):23–32

    Article  PubMed  Google Scholar 

  29. Slovis TL, Strauss KJ (2013) Gonadal shielding for neonates. Pediatr Radiol 43:1265–1266

    Article  PubMed  Google Scholar 

  30. https://www-pub.iaea.org/MTCD/Publications/PDF/Pub1543_web.pdf. Accessed 29 Jan 2019

  31. Hiorns MP, Saini A, Marsden PJ (2006) A review of current local dose-area product levels for paediatric fluoroscopy in a tertiary referral centre compared with national standards. Why are they so different? Br J Radiol 79(940):326–330

    Article  CAS  PubMed  Google Scholar 

  32. ICRP (2007) The 2007 recommendations of the international commission on radiological protection. Ann ICRP 37(2–4):1–332

    Google Scholar 

  33. Emigh B, Gordon CL, Connolly BL, Falkiner M, Thomas KE (2013) Effective dose estimation for pediatric upper gastrointestinal examinations using an anthropomorphic phantom set and metal oxide semiconductor field-effect transistor (MOSFET) technology. Pediatr Radiol 43(9):1108–1116

    Article  PubMed  Google Scholar 

  34. ICRP (2013) Radiological protection in cardiology. Ann ICRP 42(1):1–125

    Article  Google Scholar 

  35. Brenner DJ, Hall EJ (2007) Computed tomography—an increasing source of radiation exposure. New Engl J Med 357:2277–2284

    Article  CAS  PubMed  Google Scholar 

  36. Frush DP, Applegate K (2004) Computed tomography and radiation: understanding the issues. J Am Coll Radiol 1:113–119

    Article  PubMed  Google Scholar 

  37. Ward R, Carroll WD, Cunningham P et al (2017) Radiation dose from common radiological investigations and cumulative exposure in children with cystic fibrosis: an observational study from a single UK centre. BMJ Open 7(8):e017548

    Article  PubMed  PubMed Central  Google Scholar 

  38. Tomà P (2003) Radiation safety in children: what we should know. Radiol Med 105:83–91

    PubMed  Google Scholar 

  39. Arthurs OJ, Bjørkum AA (2013) Safety in pediatric imaging: an update. Acta Radiol 54(9):983–990

    Article  PubMed  Google Scholar 

  40. Callahan MJ (2011) CT dose reduction in practice. Pediatr Radiol 41(suppl 2):488–492. https://doi.org/10.1007/s00247-011-2099-y

    Article  PubMed  Google Scholar 

  41. Strauss KJ, Goske MJ, Kaste SC et al (2010) Image Gently: ten steps you can take to optimize image quality and lower CT dose for pediatric patients. AJR 194:868–873

    Article  PubMed  Google Scholar 

  42. Kalra MK, Maher MM, Toth TL et al (2004) Strategies for CT radiation dose optimization. Radiology 230:619–628

    Article  PubMed  Google Scholar 

  43. Li J, Udayasankar UK, Toth TL et al (2007) Automatic patient centering for MDCT: effect on radiation dose. AJR 188:547–552

    Article  PubMed  Google Scholar 

  44. Mahesh M (2011) Advances in CT technology and application to pediatric imaging. Pediatr Radiol 41(suppl 2):493–497. https://doi.org/10.1007/s00247-011-2169-1

    Article  PubMed  Google Scholar 

  45. Marin D, Nelson RC, Schindera ST et al (2010) Low-tube-voltage, high-tube-current multidetector abdominal CT: improved image quality and decreased radiation dose with adaptive statistical iterative reconstruction algorithm—initial clinical experience. Radiology 254:145–153

    Article  PubMed  Google Scholar 

  46. Karmazyn B, Frush DP, Applegate KE, Maxfield C, Cohen MD, Jones RP (2009) CT with a computer simulated dose reduction technique for detection of pediatric nephroureterolithiasis: comparison of standard and reduced radiation doses. AJR 192:143–149

    Article  PubMed  Google Scholar 

  47. Singh S, Kalra MK, Moore MA et al (2009) Dose reduction and compliance with pediatric CT protocols adapted to patient size, clinical indication, and number of prior studies. Radiology 252:200–208

    Article  PubMed  Google Scholar 

  48. ICRP (2000) Pregnancy and medical radiation. Ann ICRP 30(1):1–45

    Article  Google Scholar 

  49. ACR American College of Radiology. ACR-SPR practice parameter for imaging pregnant or potentially pregnant adolescents and women with ionizing radiation; https://www.acr.org/~/media/ACR/Documents/PGTS/guidelines/Pregnant_Patients.pdf/. Accessed 29 Jan 2019

  50. ACOG Committee on Obstetric Practice. Guidelines for diagnostic imaging during pregnancy (2004) ACOG Committee opinion no. 299, September 2004 (replaces no. 158, September 1995). Obstet Gynecol 104:647–651

  51. ICRP International Commission on Radiological Protection. The 2007 recommendations of the International Commission on Radiological Protection; http://www.icrp.org/publication.asp?id=ICRP%20Publication%20103. Accessed 29 Jan 2019

  52. Vock P (2017) Clinical perspective on diagnostic X-ray examinations of pregnant patients—what to take into account. Phys Med. 43:165–171

    Article  PubMed  Google Scholar 

  53. Rajaraman P, Simpson J, Neta G et al (2011) Early life exposure to diagnostic radiation and ultrasound scans and risk of childhood cancer: case-control study. BMJ 10(342):d472

    Article  Google Scholar 

  54. Health Protection Agency (2009) The Royal College of Radiologists and the College of Radiographers. Protection of Pregnant Patients during Diagnostic Medical Exposures to Ionising Radiation. https://www.rcr.ac.uk/system/files/publication/field_publication_files/HPA_preg_2nd.pdf/. Accessed 29 Jan 2019

  55. IAEA (International Atomic Energy Agency). Radiation protection of patients, Pregnant?, poster for patients; https://rpop.iaea.org/RPOP/RPoP/Content/Documents/Whitepapers/pregnancy-web.pdf/. Accessed 29 Jan 2019

  56. Tirada N, Dreizin D, Khati NJ, Akin EA, Zeman RK (2015) Imaging pregnant and lactating patients. Radiographics 35:1751–1765

    Article  PubMed  Google Scholar 

  57. Health and Safety Executive, Working safely with ionising radiation, Guidelines for expectant and breastfeeding mothers (2015) http://www.hse.gov.uk/pubns/priced/l121.pdf. Accessed 29 Jan 2019

  58. WHO Library Cataloguing-in-Publication Data. Communicating radiation risks in paediatric imaging: information to support health care dis- cussions about bene t and risk. http://www.who.int/ionizing_radiation/pub_meet/radiation-risks-paediatric-imaging/en/. Accessed 29 Jan 2019

  59. Johnson JN et al (2014) Cumulative radiation exposure and cancer risk estimation in children with heart disease. Circulation 130(2):161–167

    Article  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Paolo Tomà.

Ethics declarations

Conflict of interest

All authors declare that they have no conflict of interest.

Ethical approval

This article does not contain any studies with human participants or animal performed by any of the authors.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tomà, P., Bartoloni, A., Salerno, S. et al. Protecting sensitive patient groups from imaging using ionizing radiation: effects during pregnancy, in fetal life and childhood. Radiol med 124, 736–744 (2019). https://doi.org/10.1007/s11547-019-01034-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11547-019-01034-8

Keywords

Navigation