Abstract
Primary breast lymphoma (PBL) may mimic carcinoma clinically and also mammographic and ecographic distinction is subtle. Despite its rarity, incidence of PBLs has increased over the last four decades and continues to increase for younger women and for some subtypes, and for this reason it is increasingly important to achieve a preoperative pathological diagnosis using core needle biopsy (CNB) or fine-needle aspiration cytology (FNA). The aim of this retrospective study was to report our single-center experience in CNBs performed for histological diagnosis of PBL compared to FNA. From a total of 10,500 CNBs we found seven patients affected by PBL diagnosed at Careggi Florence University Hospital, between January 2000 and December 2016. Diffuse large B cell lymphoma (DLBCL) was the most frequent PBLs and on CNBs specimens was possible do the fluorescent in situ hybridization analysis to evaluate the presence of chromosomal translocation. CNB is an effective method for the assessment of PBLs, especially for DLBCL, in which a correct and fast classification could change the therapeutic approach and the prognosis.
This is a preview of subscription content, log in via an institution to check access.
References
Nicholson BT et al (2016) Extranodal lymphoma of the breast. Radiol Clin N Am 54(4):711–726
Thomas A et al (2017) Primary breast lymphoma in the United States: 1975–2013. J Natl Cancer Inst. doi:10.1093/jnci/djw294
Zhou K (2014) C-MYC aberrations as prognostic factors in diffuse large B-cell lymphoma: a meta-analysis of epidemiological studies. PLoS ONE 9(4):e95020
Sun Y et al (2016) Diffuse large B-cell lymphoma of the breast: prognostic factors and treatment outcomes. Onco Targets Ther 9:2069–2080
Harvey JA et al (2016) ACR appropriateness criteria palpable breast masses. J Am Coll Radiol 13(11S):e31–e42
American College of Radiology (2013) ACR BI-RADS atlas: breast imaging reporting and data system, 5th edn. ACR, Reston
Hukkinen K et al (2008) Unsuccessful preoperative biopsies, fine needle aspiration cytology or core needle biopsy, lead to increased costs in the diagnostic workup in breast cancer. Acta Oncol 47(6):1037–1045
Levine PH et al (2004) Role of fine-needle aspiration cytology in breast lymphoma. Diagn Cytopathol 30(5):332–340
Banik T et al (2016) Two cases of primary non-Hodgkin’s lymphoma of female breast: role of fine-needle aspiration cytology and cell-block immunohistochemistry. Diagn Cytopathol 44(3):235–240
Domchek SM et al (2002) Lymphomas of the breast: primary and secondary involvement. Cancer 94(1):6–13
Kiaei A et al (2016) Detection of t(8;14) c-myc/IgH gene rearrangement by long-distance polymerase chain reaction in patients with diffuse large B-cell lymphoma. Hematol Oncol Stem Cell Ther 9(4):141–146
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
All the authors declare that they have no conflict of interest.
Ethical approval
This article does not contain any studies with human participants or animals performed by any of the authors.
Rights and permissions
About this article
Cite this article
Bicchierai, G., Rigacci, L., Miele, V. et al. Role of core needle biopsy in primary breast lymphoma. Radiol med 122, 651–655 (2017). https://doi.org/10.1007/s11547-017-0773-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11547-017-0773-3