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Can MDCT or EUS features predict the histopathological grading scheme of pancreatic neuroendocrine neoplasms?

  • ABDOMINAL RADIOLOGY
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Abstract

Purpose

To identify whether the features of preoperative MDCT or EUS could predict the histopathological grading scheme of pancreatic neuroendocrine neoplasms (pNENs).

Methods

A total of 25 patients with pNENs were enrolled in the present study. The qualitative and quantitative variables were reviewed. The qualitative variables included location, contour, border, necrosis, intratumoral vessel, homogeneity, calcification, peripancreatic fat/vessel infiltration, pancreatic duct dilatation, mass within pancreas, lymphadenopathy and hepatic metastasis on MDCT and border, echogenicity, cystic/solid and blood flow on EUS. The quantitative variables included long diameter (LD), short diameter (SD), unenhanced mass attenuation (UMA), unenhanced pancreatic attenuation (UPA), arterial phase mass attenuation (APMA), arterial phase pancreatic attenuation (APPA), portal venous phase mass attenuation (PVPMA), portal venous phase pancreatic attenuation (PVPPA), arterial phase enhancement degree (APED) and portal venous phase enhancement degree (PVPED). In addition, sex and age were also evaluated. Histopathological classifications met the criterion of 2010 edition WHO Histopathological Classifications. Kruskal–Wallis test and Boruta algorithm were conducted.

Results

Lymphadenopathy and peripancreatic fat or vascular invasion foretold higher histopathological grading level while well-defined border on EUS image lower grading level.

Conclusions

Lymphadenopathy, border on EUS image and peripancreatic fat or vascular invasion can predict the histopathological grading scheme of pNENs.

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Author notes

    Authors and Affiliations

    1. Department of Radiology, Fudan University Shanghai Cancer Center, Shanghai, China

      Hui Zhu & Wei Tang

    2. Department of Oncology, Shanghai Medical College, Fudan University, 270 DongAn Road, Shanghai, 200032, China

      Hui Zhu, Wei Tang, Xiujiang Yang & Bo Sun

    3. Department of Orthopaedics, Yancheng Third People’s Hospital, The Affiliated Yancheng Hospital of Southeast University Medical College, 75 JuChang Road, Yancheng, 224001, China

      Lang Ying

    4. Department of Endoscopy, Fudan University Shanghai Cancer Center, Shanghai, China

      Xiujiang Yang & Bo Sun

    Authors
    1. Hui Zhu
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    2. Lang Ying
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    3. Wei Tang
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    Correspondence to Bo Sun.

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    Conflict of interest

    We declare that there are no conflicts of interest in this study. We have not received any funding in this study.

    Ethical standards

    All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. This article does not contain any studies with animals performed by any of the authors.

    Additional information

    H. Zhu and L. Ying contributed equally to this work.

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    Zhu, H., Ying, L., Tang, W. et al. Can MDCT or EUS features predict the histopathological grading scheme of pancreatic neuroendocrine neoplasms?. Radiol med 122, 319–326 (2017). https://doi.org/10.1007/s11547-017-0727-9

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    • DOI: https://doi.org/10.1007/s11547-017-0727-9

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