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Malignant renal neoplasms: correlation between ADC values and cellularity in diffusion weighted magnetic resonance imaging at 3 T

Neoplasie renali maligne: correlazione tra valori di ADC e cellularità nelle sequenze pesate in diffusione con risonanza magnetica a 3 T

  • Uro-Genital Radiology Radiologia Uro-Genitale
  • Published:
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Abstract

Purpose

This study aimed at exploring the feasibility of high-field diffusion-weighted magnetic resonance imaging (DW-MRI) (3 T) and to correlate apparent diffusion coefficient (ADC) values with tumour cellularity in renal malignancies.

Materials and methods

Thirty-seven patients (ten healthy volunteers and 27 patients with suspected renal malignancy) underwent T1-, T2-weighted and T1-weighted contrast-enhanced magnetic resonance imaging (MRI). Diffusion-weighted images were obtained with a single-shot spin-echo echo-planar imaging (SE-EPI) sequence with a b value of 500 s/mm2. All lesions were surgically resected, and mean tumour cellularity was calculated. Comparison between tumour cellularity and mean ADC value was performed using simple linear regression analysis.

Results

The mean ADC value in normal renal parenchyma was 2.35±0.31×10−3 mm2/s, whereas mean ADC value in renal malignancies was 1.72±0.21×10−3 mm2/s. In our population, there were no statistically significant differences between ADC values of different histological types. The analysis of mean ADC values showed an inverse linear correlation with cellularity in renal malignancies (r=−0.73, p<0.01).

Conclusions

DW-MRI is able to differentiate between normal and neoplastic renal parenchyma on the basis of tissue cellularity.

Riassunto

Obiettivo

Valutare l’utilità dell’imaging RM ad alto campo (3T) con sequenze pesate in diffusione (DWI) nello studio delle neoplasie renali e correlare i valori del coefficiente apparente di diffusione (ADC) con la cellularità delle neoplasie.

Materiali e metodi

Trentasette pazienti (10 volontari sani e 27 con lesioni renali sospette) sono stati studiati con imaging RM e sequenze T1, T2 pesate e T1 pesate dopo somministrazione di bolo di contrasto paramagnetico. Le immagini pesate in diffusione (DWI) sono state acquisite con sequenza sSH SE-EPI e fattore b di 500 s/mm2. Per ogni lesione chirurgicamente asportata è stata valutata la cellularità media. L’analisi di regressione lineare semplice è stata utilizzata per valutare la correlazione fra cellularità tumorale e valore ADC.

Risultati

L’ADC medio nel parenchima dei pazienti sani è stato 2,35±0,31×10−3 mm2/s. Il valore medio nei tumori renali maligni era di 1,72±0,21×10−3 mm2/s. Non è stata riscontrata una differenza statisticamente significativa tra i valori medi di ADC dei differenti istotipi neoplastici. È stata documentata una correlazione inversa fra il valore medio di ADC e la cellularità media nei tumori renali maligni (r=−0,73, p<0,01).

Conclusioni

L’imaging in diffusione consente una distinzione significativa tra parenchima renale normale e neoplastico. È possibile differenziare i tessuti neoplastici sulla base della cellularità.

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Authors and Affiliations

  1. Dipartimento di Diagnostica per Immagini, Imaging Molecolare, Radiologia Interventistica e Radioterapia, Policlinico Universitario “Tor Vergata” di Roma, Viale Oxford 81, 00133, Roma, Italy

    G. Manenti, M. Di Roma, S. Mancino, D. A. Bartolucci, R. Mastrangeli, E. Squillaci & G. Simonetti

  2. Dipartimento di Anatomia Patologica, Policlinico Universitario “Tor Vergata” di Roma, Viale Oxford 81, 00133, Roma, Italy

    G. Palmieri

  3. Dipartimento di Urologia, Policlinico Universitario “Tor Vergata” di Roma, Viale Oxford 81, 00133, Roma, Italy

    R. Miano

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  1. G. Manenti
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  2. M. Di Roma
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  3. S. Mancino
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  4. D. A. Bartolucci
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  5. G. Palmieri
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  6. R. Mastrangeli
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  7. R. Miano
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  8. E. Squillaci
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  9. G. Simonetti
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Correspondence to G. Manenti.

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Manenti, G., Di Roma, M., Mancino, S. et al. Malignant renal neoplasms: correlation between ADC values and cellularity in diffusion weighted magnetic resonance imaging at 3 T. Radiol med 113, 199–213 (2008). https://doi.org/10.1007/s11547-008-0246-9

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  • DOI: https://doi.org/10.1007/s11547-008-0246-9

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