Skip to main content
SpringerLink
Log in

Clinical activity of sunitinib in patients with advanced desmoplastic round cell tumor: a case series

  • Day-to-Day Practice
  • Published:
Targeted Oncology Aims and scope Submit manuscript

Abstract

Desmoplastic small round cell tumor (DSRCT) is a rare and aggressive malignancy with poor outcome occurring in adolescents and young adults. Therapeutic options for patients with advanced disease are limited. Preclinical studies have shown that VEGFR-2 and VEGFA are overexpressed in DSRCT and that DSRCT xenografts were highly responsive to anti-VEGF agents such as bevacizumab. We report here the clinical activity of sunitinib in eight patients with DSCRT. Our data suggest that sunitinib may be associated with clinical benefit even in heavily pretreated patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Fletcher CDM, Unni KK, Mertens F (eds) (2002) World Health Organisation classification of tumours. Pathology and genetics of tumours of soft tissue and bone. IARC Press, Lyon

    Google Scholar 

  2. Hayes-Jordan A, Anderson PM (2011) The diagnosis and management of desmoplastic small round cell tumor: a review. Curr Opin Oncol 23:385–389

    Article  PubMed  Google Scholar 

  3. Magnan HD, Chou T, LaQuaglia MP, Gerald W, Ladanyi M, Merchant MS (2009) Elevated expression of VEGFR-2 and VEGFA in desmoplastic small round cell tumor (DSRCT) and activity of bevacizumab and irinotecan in a xenograft model of DSRCT. J Clin Oncol 27:15s, suppl; abstr 10016

    Article  Google Scholar 

  4. Chow LQM, Eckhardt SG (2007) Sunitinib: from rational design to clinical efficacy. J Clin Oncol 25:884–896

    Article  PubMed  CAS  Google Scholar 

  5. George S, Merriam P, Maki RG, Van den Abbeele AD, Yap JT, Akhurst T, Harmon DC, Bhuchar G, O'Mara MM, D'Adamo DR, Morgan J, Schwartz GK, Wagner AJ, Butrynski JE, Demetri GD, Keohan ML (2009) Multicenter phase II trial of sunitinib in the treatment of nongastrointestinal stromal tumor sarcomas. J Clin Oncol 27:3154–3160

    Article  PubMed  CAS  Google Scholar 

  6. Froberg K, Brown RE, Gaylord H, Manivel C (1999) Intra-abdominal desmoplastic small round cell tumor: immunohistochemical evidence for up-regulation of autocrine and paracrine growth factors. Ann Clin Lab Sci 29:78–85

    PubMed  CAS  Google Scholar 

Download references

Conflict of interest

The authors declare that they have no conflict of interest.

Author information

Authors and Affiliations

  1. Department of Medical Oncology, Institut Bergonie, 229 Cours de l’Argonne, 33076, Bordeaux, France

    Antoine Italiano & Binh Bui

  2. Department of Radiology, Institut Bergonié, Bordeaux, France

    Michèle Kind

  3. Department of Medicine, Institut Gustave Roussy, Villejuif, France

    Angela Cioffi

  4. Sarcoma Service, Memorial Sloan-Kettering Cancer Center, New York, USA

    Robert G. Maki

  5. Mount Sinai School of Medicine, New York, NY, USA

    Robert G. Maki

Authors
  1. Antoine Italiano
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michèle Kind
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Angela Cioffi
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Robert G. Maki
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Binh Bui
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Antoine Italiano.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Italiano, A., Kind, M., Cioffi, A. et al. Clinical activity of sunitinib in patients with advanced desmoplastic round cell tumor: a case series. Targ Oncol 8, 211–213 (2013). https://doi.org/10.1007/s11523-012-0251-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11523-012-0251-8

Keywords

Search

Navigation