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Visco-hyperelastic characterization of human brain white matter micro-level constituents in different strain rates

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Abstract

In this study, we propose a computational characterization technique for obtaining the material properties of axons and extracellular matrix (ECM) in human brain white matter. To account for the dynamic behavior of the brain tissue, data from time-dependent relaxation tests of human brain white matter in different strain rates are extracted and formulated by a visco-hyperelastic constitutive model consisting of the Ogden hyperelastic model and the Prony series expansion. Through micromechanical finite element simulation, a derivative-free optimization framework designed to minimize the difference between the numerical and experimental data is used to identify the material properties of the axons and ECM. The Prony series expansion parameters of axons and ECM are found to be highly affected by the Prony series expansion coefficients of the brain white matter. The optimal parameters of axons and ECM are verified through micromechanical simulation by comparing the averaged numerical response with that of the experimental data. Moreover, the initial shear modulus and the reduced shear modulus of the axons are found for different strain rates of 0.0001, 0.01, and 1 s−1. Consequently, first- and second-order regressions are used to find relations for the prediction of the shear modulus at the intermediate strain rates.

The applied procedure for characterization of brain white matter micro-level constituents. The macro-level experimental data in different strain rates are used in the context of simulation-based optimization to obtain the properties of axons and extracellular matrix material.

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Authors and Affiliations

  1. Department of Mechanical Engineering, North Dakota State University, Fargo, ND, USA

    Mohammadreza Ramzanpour, Mohammad Hosseini-Farid, Jayse McLean, Mariusz Ziejewski & Ghodrat Karami

  2. Department of Orthopedic Surgery, Mayo Clinic, Rochester, MN, USA

    Mohammad Hosseini-Farid

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  1. Mohammadreza Ramzanpour
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  3. Jayse McLean
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Correspondence to Ghodrat Karami.

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Ramzanpour, M., Hosseini-Farid, M., McLean, J. et al. Visco-hyperelastic characterization of human brain white matter micro-level constituents in different strain rates. Med Biol Eng Comput 58, 2107–2118 (2020). https://doi.org/10.1007/s11517-020-02228-3

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