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Assessment of tobacco smoke effects on neonatal cardiorespiratory control using a semi-automated processing approach

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Abstract

A semi-automated processing approach was developed to assess the effects of early postnatal environmental tobacco smoke (ETS) on the cardiorespiratory control of newborn lambs. The system consists of several steps beginning with artifact rejection, followed by the selection of stationary segments, and ending with feature extraction. This approach was used in six lambs exposed to 20 cigarettes/day for the first 15 days of life, while another six control lambs were exposed to room air. On postnatal day 16, electrocardiograph and respiratory signals were obtained from a 6-h polysomnographic recording. The effects of postnatal ETS exposure on heart rate variability, respiratory rate variability, and cardiorespiratory interrelations were explored. The unique results suggest that early postnatal ETS exposure increases respiratory rate variability and decreases the coupling between cardiac and respiratory systems. Potentially harmful consequences in early life include unstable breathing and decreased adaptability of cardiorespiratory function, particularly during early life challenges, such as prematurity or viral infection.

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Acknowledgments

We would like to thank the biostatistician of the LTSI, Mrs. Nathalie Costet, for her assistance in the statistical analysis.

Funding

This study was supported by the Canada Research Chair in Neonatal Respiratory Physiology allocated to JP Praud and by the French Brittany council.

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Authors and Affiliations

  1. University of Rennes, CHU Rennes, INSERM, LTSI-UMR 1099, F-3500, Rennes, France

    Sally Al-Omar, Virginie Le Rolle, Alain Beuchée & Guy Carrault

  2. Université de Sherbrooke, Sherbrooke, QC, Canada

    Sally Al-Omar, Nathalie Samson & Jean-Paul Praud

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  1. Sally Al-Omar
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  2. Virginie Le Rolle
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  3. Alain Beuchée
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Correspondence to Virginie Le Rolle.

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All applicable guidelines from the Canadian Council on Animal Care were followed. All procedures performed in the present study involving animals were in accordance with the ethical standards of the University of Sherbrooke, where the studies were conducted.

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Al-Omar, S., Le Rolle, V., Beuchée, A. et al. Assessment of tobacco smoke effects on neonatal cardiorespiratory control using a semi-automated processing approach. Med Biol Eng Comput 56, 2025–2037 (2018). https://doi.org/10.1007/s11517-018-1827-y

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