Tracking and detection of epileptiform activity in multichannel ictal EEG using signal subspace correlation of seizure source scalp topographies

Abstract

Conventional methods for monitoring clinical (epileptiform) multichannel electroencephalogram (EEG) signals often involve morphological, spectral or time–frequency analysis on individual channels to determine waveform features for detecting and classifying ictal events (seizures) and inter-ictal spikes. Blind source separation (BSS) methods, such as independent component analysis (ICA), are increasingly being used in biomedical signal processing and EEG analysis for extracting a set of underlying source waveforms and sensor projections from multivariate time-series data, some of which reflect clinically relevant neurophysiological (epileptiform) activity. The work presents an alternative spatial approach to source tracking and detection in multichannel EEG that exploits prior knowledge of the spatial topographies of the sensor projections associated with the target sources. The target source sensor projections are obtained by ICA decomposition of data segments containing representative examples of target source activity, e.g. a seizure or ocular artifact. Source tracking and detection are then based on the subspace correlation between individual target sensor projections and the signal subspace over a moving window. Different window lengths and subspace correlation threshold criteria reflect transient or sustained target source activity. To study the behaviour and potential application of this spatial source tracking and detection approach, the method was used to detect (transient) ocular artifacts and (sustained) seizure activity in two segments of 25-channel EEG data recorded from one epilepsy patient on two separate occasions, with promising and intuitive results.