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Analysis of Flow Phenomena in Gastric Contents Induced by Human Gastric Peristalsis Using CFD

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Abstract

This paper uses computational fluid dynamics to simulate and analyze intragastric fluid motions induced by human peristalsis. We created a two-dimensional computational domain of the distal stomach where peristalsis occurs. The motion of the gastric walls induced by an antral contraction wave (ACW) on the wall of the computational domain was well simulated using a function defined in this study. Retropulsive flow caused by ACW was observed near the occluded region, reaching its highest velocity of approximately 12 mm/s in the narrowest region. The viscosity of the model gastric contents applied in this study hardly affected the highest velocity, but greatly affected the velocity profile in the computational domain. The shear rate due to gastric fluid motion was calculated using the numerical output data. The shear rate reached relatively high values of approximately 20 s−1 in the most occluded region. The shear rate profile was almost independent of the fluid viscosity. We also simulated mass transfer of a gastric digestive enzyme (pepsin) in model gastric content when peristalsis occurs on the gastric walls. The visualized simulation results suggest that gastric peristalsis is capable of efficiently mixing pepsin secreted from the gastric walls with an intragastric fluid.

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Authors and Affiliations

  1. Food Engineering Division, National Food Research Institute, NARO, 2-1-12 Kannondai, Tsukuba, Ibaraki, 305-8642, Japan

    Hiroyuki Kozu, Isao Kobayashi, Mitsutoshi Nakajima & Kunihiko Uemura

  2. Graduate School of Life and Environmental Sciences, University of Tsukuba, Tennoudai, Tsukuba, Ibaraki, 305-8572, Japan

    Hiroyuki Kozu, Mitsutoshi Nakajima, Seigo Sato & Sosaku Ichikawa

Authors
  1. Hiroyuki Kozu
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  2. Isao Kobayashi
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  3. Mitsutoshi Nakajima
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  4. Kunihiko Uemura
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  5. Seigo Sato
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  6. Sosaku Ichikawa
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Correspondence to Isao Kobayashi or Sosaku Ichikawa.

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Kozu, H., Kobayashi, I., Nakajima, M. et al. Analysis of Flow Phenomena in Gastric Contents Induced by Human Gastric Peristalsis Using CFD. Food Biophysics 5, 330–336 (2010). https://doi.org/10.1007/s11483-010-9183-y

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  • DOI: https://doi.org/10.1007/s11483-010-9183-y

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