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Can Humanized Mice Reflect the Complex Pathobiology of HIV-Associated Neurocognitive Disorders?

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Abstract

There is a rebirth of humanized mouse models in reflecting human immunodeficiency virus (HIV) pathobiology. This has allowed new investigations of viral diversity, immunity and developmental therapeutics. In the past, HIV infection and disease were, in part, mirrored in immune deficient mice reconstituted with human hematopoietic stem cells. What remained from early studies reflected the ability to mirror central nervous system (CNS) disease. As the wide spread use of combination antiretroviral therapies has changed the severity, but not prevalence, of HIV-associated neurocognitive disorders (HAND), mimicking such virus-induced CNS morbidities in humanized animals is essential for HIV/AIDS research activities. To this end, we now review the evidence for how and under what circumstances humanized mice may be utilized for studies of HIV-1 neuropathogenesis.

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Acknowledgements

This work was supported by National Institutes of Health Grants R21NS060642, 1P01 DA028555, P20 RR15635, 1 P01 NS043985-01, 2R37 NS36126, 5 P01 DA026146, and 5 P01 MH64570-03. We acknowledge Edward Makarov, Jaclyn Knibbe, Prashanta Dash, Tanuja Gutti and Adrian Epstein for excellent contributions made to the laboratories ongoing scientific investigations.

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There are no conflicts of interest for any of the authors.

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Authors and Affiliations

  1. Department of Pharmacology and Experimental Neuroscience and Center for Neurodegenerative Disorders, University of Nebraska Medical Center, Omaha, NE, USA

    Santhi Gorantla, Howard E. Gendelman & Larisa Y. Poluektova

  2. Department of Pharmacology and Experimental Neuroscience, 985880 Nebraska Medical Center, Omaha, NE, USA

    Larisa Y. Poluektova

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  1. Santhi Gorantla
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  2. Howard E. Gendelman
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  3. Larisa Y. Poluektova
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Correspondence to Larisa Y. Poluektova.

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Gorantla, S., Gendelman, H.E. & Poluektova, L.Y. Can Humanized Mice Reflect the Complex Pathobiology of HIV-Associated Neurocognitive Disorders?. J Neuroimmune Pharmacol 7, 352–362 (2012). https://doi.org/10.1007/s11481-011-9335-y

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  • DOI: https://doi.org/10.1007/s11481-011-9335-y

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