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Role of β-Catenin/TCF-4 Signaling in HIV Replication and Pathogenesis: Insights to Informing Novel Anti-HIV Molecular Therapeutics

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Abstract

A greater understanding of the interaction between HIV and host signaling pathways that restrict virus production may lead to new methods to purge virus from latent reservoirs and enhance survival/function of cells targeted by HIV. This review highlights the role of the Wnt/β-catenin pathway as a host factor that represses HIV replication in multiple targets, especially those relevant to HIV in the central nervous system.

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Acknowledgment

This work was supported by NIH grants R01 NS060632 (LA), R21 A1077329 (LA), PO1 AI082971 (LA), and F31 NS071999 (LJH). The studies were also supported by the Chicago Developmental Center for AIDS Research (D-CFAR, P30 AI 082151), an NIH-funded program supported by NIAID, NCI, NIMH, NIDA, NICHD, NHLBI, and NCCAM.

Conflict of interest

Dr. L. Al-Harthi has a pending US patent on Wnt/β-catenin-based therapeutics.

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  1. Department of Immunology/Microbiology and Center for AIDS Research, Rush University Medical Center, Chicago, IL, 60607, USA

    Lisa J. Henderson & Lena Al-Harthi

  2. Department of Immunology and Microbiology, Rush University Medical Center, 1735 W. Harrison Street, 614 Cohn, Chicago, IL, 60612, USA

    Lena Al-Harthi

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  1. Lisa J. Henderson
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Correspondence to Lena Al-Harthi.

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Henderson, L.J., Al-Harthi, L. Role of β-Catenin/TCF-4 Signaling in HIV Replication and Pathogenesis: Insights to Informing Novel Anti-HIV Molecular Therapeutics. J Neuroimmune Pharmacol 6, 247–259 (2011). https://doi.org/10.1007/s11481-011-9266-7

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