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DNA Detection Based on Localized Surface Plasmon Resonance Spectroscopy of Ag@Au Biocomposite Nanoparticles

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Abstract

Noble metal nanoparticles (NPs) have attracted much attention due to their unique physical and chemical properties such as tunable surface plasmonics, high-efficiency electrochemical sensing, and enhanced fluorescence. We produced two biosensor chips consisting of Ag@Au bimetallic nanoparticles (BNPs) on a carbon thin film by simple RF-sputtering and RF-plasma-enhanced chemical vapor co-deposition. We deposited Au NPs with average size of 4 nm (Au1 NPs) or 11 nm (Au2 NPs) on a sensor chip consisting of Ag NPs with mean size of 15 nm, and we investigated the effect of shell size (Au NPs) on the chemical activities of the resulting Ag@Au1 BNPs and Ag@Au2 BNPs. We estimated the average size and morphology of Ag@Au BNPs by scanning electron microscopy (SEM) and atomic force microscopy (AFM) images. X-ray diffraction (XRD) patterns revealed that Ag NPs and Au NPs had face-centered cubic (FCC) structure. We studied aging of the biosensor chips consisting of Ag@Au BNPs by localized surface plasmon resonance (LSPR) spectroscopy for up to 3 months. UV–visible aging of the prepared samples indicated that Ag@Au1 BNPs, which corresponded to Ag NPs covered with smaller Au NPs, were more chemically active than Ag@Au2 BNPs. Furthermore, we evaluated changes in the LSPR absorption peaks of Ag@Au1 BNPs and bare Ag NPs in the presence of a DNA primer decamer at fM concentrations, to find that Ag@Au1 BNPs were more sensitive biosensor chips within a short response time as compared to bare Ag NPs.

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Acknowledgments

We would like to thank Dr. M. A. Vesaghi for discussion about AFM data, Dr. H. Mobasheri and Mr. K. Z. Salimi for DNA solvent, and C.M.C.P. Manso for reviewing the text.

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Author notes

  1. Oswaldo Baffa

    Present address: Department of Physics, FFCLRP, University of São Paulo, Ribeirão Preto, SP, Brazil

Authors and Affiliations

  1. School of Physics, Institute for Research in Fundamental Sciences, PO Box 19395-5531, Tehran, Iran

    Soudabeh Arsalani

  2. Nano Mabna Iranian Inc., P.O. Box 1676664116, Tehran, Iran

    Tayebeh Ghodselahi

  3. Department of Physics, Central Tehran Branch, Islamic Azad University, Tehran, Iran

    Tiam Neishaboorynejad

Authors
  1. Soudabeh Arsalani
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  2. Tayebeh Ghodselahi
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  3. Tiam Neishaboorynejad
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  4. Oswaldo Baffa
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Correspondence to Soudabeh Arsalani.

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Arsalani, S., Ghodselahi, T., Neishaboorynejad, T. et al. DNA Detection Based on Localized Surface Plasmon Resonance Spectroscopy of Ag@Au Biocomposite Nanoparticles. Plasmonics 14, 1419–1426 (2019). https://doi.org/10.1007/s11468-019-00937-6

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  • DOI: https://doi.org/10.1007/s11468-019-00937-6

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