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Application of a Plasmonic Biosensor for Detection of Human Blood Groups

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Abstract

A recently published plasmonic biosensor based on birefringent solid-core microstructured optical fiber is applied for the detection of human blood groups. The birefringent behavior is obtained by removing five central air holes of a two-ring hexagonal lattice of holes in a gold-covered silica fiber with the blood layer surrounding the fiber. The sensing performance of two resonant modes (I based on a phase matching point and II based on a loss matching point) are analyzed. For an increase of the refractive index from 1.3768 (human blood group A) to 1.3796 (human blood group O), the resonance spectral width δλ 0.5 is decreased from 26.8 to 25.8 nm for the core mode I and δλ 0.5 is increased from 28.3 to 33.2 nm for the core mode II. In addition, the amplitude sensitivity S A is increased from 329.7 to 372.2 RIU−1 for the core mode I and S A is decreased from 298.2 to 283.7 RIU−1 for the core mode II. The average value (26.20 nm for core mode I and 31.07 nm for core mode II) of δλ 0.5 from the human blood groups A, B, and O for our plasmonic biosensor is smaller in comparison with a recently published average value (39.10 nm) of the full width at half maximum (FWHM). Our biosensor can be calibrated for a glycerol-water solution by using the linear dependence between the refractive index n a and the mass fraction w of the solutes.

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  1. Department of Physics, University Politehnica of Bucharest, 060042, Bucharest, Romania

    V. A. Popescu

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  1. V. A. Popescu
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Correspondence to V. A. Popescu.

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Popescu, V.A. Application of a Plasmonic Biosensor for Detection of Human Blood Groups. Plasmonics 12, 1733–1739 (2017). https://doi.org/10.1007/s11468-016-0440-x

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  • DOI: https://doi.org/10.1007/s11468-016-0440-x

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