Skip to main content
Log in

Gold nanocages as multifunctional materials for nanomedicine

  • Review Article
  • Published:
Frontiers of Physics Aims and scope Submit manuscript

Abstract

Featured by tunable localized surface plasmon resonance peaks in the near-infrared region and hollow interiors, Au nanocages represent a novel class of multifunctional nanomaterials that have gained considerable attention in recent years. This short review summarizes our recent work on the capabilities of Au nanocages in nanomedicine. We start with a brief description of the synthesis of Au nanocages and highlight our recent protocols for the scaled-up production of Au nanocages. We then use a number of examples to illustrate how Au nanocages can contribute to nanomedicine with respect to both diagnosis and therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. K. Riehemann, S. W. Schneider, T. A. Luger, B. Godin, M. Ferrari, and H. Fuchs, Angew. Chem. Int. Ed., 2009, 48: 872

    Article  Google Scholar 

  2. S. M. Moghimi, A. C. Hunter, and J. C. Murray, FASEB J., 2005, 19(3): 311

    Article  Google Scholar 

  3. N. L. Rosi and C. A. Mirkin, Chem. Rev., 2005, 105(4): 1547

    Article  Google Scholar 

  4. E. Boisselier and D. Astruc, Chem. Soc. Rev., 2009, 38(6): 1759

    Article  Google Scholar 

  5. O. C. Farokhzad and R. Langer, Adv. Drug Deliv. Rev., 2006, 58(14): 1456

    Article  Google Scholar 

  6. S. E. Skrabalak, J. Chen, L. Au, X. Lu, X. Li, and Y. Xia, Adv. Mater., 2007, 19(20): 3177

    Article  Google Scholar 

  7. S. Lal, S. E. Clare, and N. J. Halas, Acc. Chem. Res., 2008, 41(12): 1842

    Article  Google Scholar 

  8. P. K. Jain, X. Huang, I. H. El-Sayed, and M. A. El-Sayed, Acc. Chem. Res., 2008, 41(12): 1578

    Article  Google Scholar 

  9. C. J. Murphy, A. M. Gole, J. W. Stone, P. N. Sisco, A. M. Alkilany, E. C. Goldsmith, and S. C. Baxter, Acc. Chem. Res., 2008, 41(12): 1721

    Article  Google Scholar 

  10. C. M. Cobley, J. Chen, E. C. Cho, L. V. Wang, and Y. Xia, Chem. Soc. Rev., 2011, 40(1): 44

    Article  Google Scholar 

  11. K. Kelly, E. Coronado, L. Zhao, and G. C. Schatz, J. Phys. Chem. B, 2003, 107: 668

    Article  Google Scholar 

  12. B. J. Wiley, S. H. Im, Z. Y. Li, J. McLellan, A. R. Siekkinen, and Y. Xia, J. Phys. Chem. B, 2006, 110(32): 15666

    Article  Google Scholar 

  13. R. Weissleder, Nat. Biotechnol., 2001, 19(4): 316

    Article  Google Scholar 

  14. M. Hu, J. Chen, Z. Y. Li, L. Au, G. V. Hartland, X. Li, M. Marquez, and Y. Xia, Chem. Soc. Rev., 2006, 35(11): 1084

    Article  Google Scholar 

  15. J. Rodríguez-Fernández, J. Pérez-Juste, F. J. García de Abajo, and L. M. Liz-Marzán, Langmuir, 2006, 22(16): 7007

    Article  Google Scholar 

  16. Y. Sun, B. T. Mayers, and Y. Xia, Nano Lett., 2002, 2: 481

    Article  ADS  Google Scholar 

  17. Y. Sun and Y. Xia, Science, 2002, 298(5601): 2176

    Article  ADS  Google Scholar 

  18. Y. Sun and Y. Xia, J. Am. Chem. Soc., 2004, 126(12): 3892

    Article  Google Scholar 

  19. S. E. Skrabalak, L. Au, X. Li, and Y. Xia, Nat. Protoc., 2007, 2(9): 2182

    Article  Google Scholar 

  20. S. E. Skrabalak, J. Chen, Y. Sun, X. Lu, L. Au, C. M. Cobley, and Y. Xia, Acc. Chem. Res., 2008, 41(12): 1587

    Article  Google Scholar 

  21. S. E. Skrabalak, B. J. Wiley, M. Kim, E. V. Formo, and Y. Xia, Nano Lett., 2008, 8(7): 2077

    Article  ADS  Google Scholar 

  22. X. Xia, J. Zeng, L. K. Oetjen, Q. Li, and Y. Xia, J. Am. Chem. Soc., 2012, 134(3): 1793

    Article  Google Scholar 

  23. B. Wiley, T. Herricks, Y. Sun, and Y. Xia, Nano Lett., 2004, 4: 1733

    Article  ADS  Google Scholar 

  24. A. R. Siekkinen, J. M. McLellan, J. Chen, and Y. Xia, Chem. Phys. Lett., 2006, 432(4–6): 491

    Article  ADS  Google Scholar 

  25. Q. Zhang, C. Cobley, L. Au, M. McKiernan, A. Schwartz, L. P. Wen, J. Chen, and Y. Xia, ACS Appl. Mater. Interfaces, 2009, 1(9): 2044

    Article  Google Scholar 

  26. Q. Zhang, W. Li, L. P. Wen, J. Chen, and Y. Xia, Chem. Eur. J., 2010, 16(33): 10234

    Article  Google Scholar 

  27. A. Mooradian, Phys. Rev. Lett., 1969, 22: 185

    Article  ADS  Google Scholar 

  28. L. Au, Q. Zhang, C. M. Cobley, M. Gidding, A. G. Schwartz, J. Chen, and Y. Xia, ACS Nano, 2010, 4(1): 35

    Article  Google Scholar 

  29. L. Tong, C. M. Cobley, J. Chen, Y. Xia, and J.X. Cheng, Angew. Chem. Int. Ed., 2010, 49: 3485

    Article  Google Scholar 

  30. X. Yang, E. W. Stein, S. Ashkenazi, and L. V. Wang, Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol., 2009, 1(4): 360

    Article  Google Scholar 

  31. K. H. Song, C. Kim, C. M. Cobley, Y. Xia, and L. V. Wang, Nano Lett., 2009, 9(1): 183

    Article  ADS  Google Scholar 

  32. C. Kim, C. Favazza, and L. V. Wang, Chem. Rev., 2010, 110(5): 2756

    Article  Google Scholar 

  33. X. Yang, S. E. Skrabalak, Z. Y. Li, Y. Xia, and L. V. Wang, Nano Lett., 2007, 7(12): 3798

    Article  ADS  Google Scholar 

  34. C. Kim, E. C. Cho, J. Chen, K. H. Song, L. Au, C. Favazza, Q. Zhang, C. M. Cobley, F. Gao, Y. Xia, and L. V. Wang, ACS Nano, 2010, 4(8): 4559

    Article  Google Scholar 

  35. L. R. Hirsch, R. J. Stafford, J. A. Bankson, S. R. Sershen, B. Rivera, R. E. Price, J. D. Hazle, N. J. Halas, and J. L. West, Proc. Natl. Acad. Sci. USA, 2003, 100(23): 13549

    Article  ADS  Google Scholar 

  36. X. Huang, P. K. Jain, I. H. El-Sayed, and M. A. El-Sayed, Lasers Med. Sci., 2008, 23(3): 217

    Article  Google Scholar 

  37. X. Huang, I. H. El-Sayed, W. Qian, and M. A. El-Sayed, J. Am. Chem. Soc., 2006, 128(6): 2115

    Article  Google Scholar 

  38. W. Hasan, C. L. Stender, M. H. Lee, C. L. Nehl, J. Lee, and T. W. Odom, Nano Lett., 2009, 9(4): 1555

    Article  ADS  Google Scholar 

  39. J. Chen, D. Wang, J. Xi, L. Au, A. Siekkinen, A. Warsen, Z. Y. Li, H. Zhang, Y. Xia, and X. Li, Nano Lett., 2007, 7(5): 1318

    Article  ADS  Google Scholar 

  40. J. Chen, F. Saeki, B. J. Wiley, H. Cang, M. J. Cobb, Z. Y. Li, L. Au, H. Zhang, M. B. Kimmey, X. Li, and Y. Xia, Nano Lett., 2005, 5(3): 473

    Article  ADS  Google Scholar 

  41. J. Chen, C. Glaus, R. Laforest, Q. Zhang, M. Yang, M. Gidding, M. J. Welch, and Y. Xia, Small, 2010, 6(7): 811

    Article  Google Scholar 

  42. M. S. Yavuz, Y. Cheng, J. Chen, C. M. Cobley, Q. Zhang, M. Rycenga, J. Xie, C. Kim, K. H. Song, A. G. Schwartz, L. V. Wang, and Y. Xia, Nat. Mater., 2009, 8(12): 935

    Article  ADS  Google Scholar 

  43. G.D. Moon, S.W. Choi, X. Cai, W. Li, E. C. Cho, U. Jeong, L. V. Wang, and Y. Xia, J. Am. Chem. Soc., 2011, 133(13): 4762

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Younan Xia.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Xia, X., Xia, Y. Gold nanocages as multifunctional materials for nanomedicine. Front. Phys. 9, 378–384 (2014). https://doi.org/10.1007/s11467-013-0318-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11467-013-0318-8

Keywords

Navigation