Skip to main content
SpringerLink
Log in

Preparation and characterization of 3-(triethoxysilyl) propyl isocyanate self-assembled monolayer on surface of chip

  • Articles/Analytical Chemistry
  • Published:
Chinese Science Bulletin

Abstract

Monolayer of 3-(triethoxysilyl) propyl isocyanate was prepared on the slide by self-assembled technique. X-ray photoelectron spectroscopy (XPS) was employed to analyze the elementary composition of the film. Contact angle of distilled water was measured to characterize the surface state. It was shown that 3-(triethoxysilyl) propyl isocyanate had been successfully assembled on the slide. The increase of contact angle to 80° demonstrated that the hydrophobicity of the surface of chip was increased significantly. Moreover, further self-assembly of bovine serum albumin (BSA) on 3-(triethoxysilyl) propyl isocyanate was also carried out with the advantages such as simple and convenient preparation. Therefore, the potential of broader applications in the modification of micro-channel in the μ-TAS system, the immobilization of protein or peptide and the surface modification of materials are all expectative.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Decher G, Hong J D, Schmitt J. Buildup of ultrathin multiplayer films by a self-assembly process: III. Connectively alternating adsorption of anionic and cationic polyeletrolytes on charger surface. Thin Solid Films, 1992, 210/211: 831–835

    Article  Google Scholar 

  2. Bhushan B, Kulkami A V, Koinkar V N, et al. Microtribological characterization of self-assembled and langmuir-blodgett monolayers by atomic and friction force microscopy. Langmuir, 1995, 11: 3189–3198

    Article  Google Scholar 

  3. Suasnnah C C, Paul F N. Lateral force microscopy study of the frictional behavior of self-assembled monolayers of octadecyltrichlorosilane on silicon/silicon dioxide immersed in nalcohols. Langmuir, 2001, 17: 720–732

    Article  Google Scholar 

  4. Kataoka K, Kwon G S, Yokoyama M, et al. Block copolymer micelles as vehicles for drug delivery. J Control Release, 1993, 24: 119–132

    Article  Google Scholar 

  5. Osada K, Kataoka K. Drug and gene delivery based on supramolecular assembly of PEG-polypeptide hybrid block copolymers. Adv Polym Sci, 2006, 202: 113–153

    Article  Google Scholar 

  6. Chung A J, Rubner M F. Methods of loading and releasing low molecular weight cationic molecules in weak polyelectrolyte multilayer films. Langmuir, 2002, 18: 1176–1183

    Article  Google Scholar 

  7. Pei R J, Cui X, Yang X R, et al. Assembly of alternating polycation and DNA multilayer films by electrostatic layer-by-layer adsorption. Biomacromolecules, 2001, 2(2): 463–468

    Article  Google Scholar 

  8. Zhao X J, Mu Y, Wang Z, et al. Studies on an immunosensor of album in based on surface plasmon resonance (in Chinese). Chem J Chinese U, 1999, 20(5): 704–708

    Google Scholar 

  9. Bai Y, Ma L, Liu Z M, et al. Development of DNA electrochemical sensor DNA. J Transducer Technol, 2002, 21(9): 62–64

    Google Scholar 

  10. Li C X, Li J, Xiao L T, et al. Amperometric immunosensor based on mercapto carboxylic acid self assembled monolayer for phytohormone indoleacetic acid assay. Acta Chim Sin, 2003, 61(5): 790–794

    Google Scholar 

  11. Chen X D, Jiang S G, Liu M H. DNA-based molecular device. Prog Chem, 2003, 15(4): 332–337

    Google Scholar 

  12. Zhu C L, Liu Y P, Huang W H, et al. DNA as a template in directing the self-assembly of nanoparticles. Physics, 2003, 32(8): 515–519

    Google Scholar 

  13. Edel Figueiredo Barbosa-Stancioli G I A, Herman Sander Mansur A A P M W L V. Small-angle X-ray scattering and FTIR characterization of nanostructured poly (vinyl alcohol)/silicate hybrids for immunoassay applications. J Mater Sci, 2008, 43(2): 1–14

    Google Scholar 

  14. Gervasio G, Marabello D, Sappa E, et al. Reactions of Ru3(CO)12 with 2-pentynal-diethyl-acetal. The crystal structure of Ru2(CO)6 [μ-η4-{EtC2C(H)(OEt)2}CO{EtC2C(H)(OEt)2}] and its reactivity towards tetraethylorthosilicate. J Organomet Chem, 2005, 690: 3730–3736

    Article  Google Scholar 

  15. Wang Q M, Yan B. Novel luminescent molecular-based hybrid organic-inorganic terbium complex covalently bonded materials via sol-gel process. Inorg Chem Commun, 2004, 7: 747–750

    Article  Google Scholar 

  16. Wang Q M, Yan B. Terbium/zinc luminescent hybrid siloxane-oxide materials bridged by novel ureasils linkages. J Organomet Chem, 2006, 691: 545–550

    Article  Google Scholar 

  17. Sui Y L, Yan B. Fabrication and photoluminescence of molecular hybrid films based on the complexes of 8-hydroxyquinoline with different metal ions via sol-gel process. J Photochem Photobiol A Chem, 2006, 182: 1–6

    Article  Google Scholar 

  18. Yan B, Zhou B, Wang Q M. Novel hybrid materials with covalent bonding and rare earthions-induced enhancing luminescence of bridged 9-amino acridine. J Lumin, 2007, 126: 556–560

    Article  Google Scholar 

  19. Yan B, Wang F F. Molecular design and photo-physics of quaternary hybrid terbium centered systems with novel functional di-urea linkages of strong chemical bonds through hydrogen transfer addition. J Organomet Chem, 2007, 692(12): 2395–2401

    Article  Google Scholar 

  20. Wang H M, Cong H, Sun C L, et al. Rapid separation of lipoproteins based on microfluidic chip electrophoresis. Acta Chim Sin, 2006, 64(7): 705–708

    Google Scholar 

  21. Badal M Y, Wong M, Chiem N, et al. Protein separation and surfactant control of electroosmotic flow in poly(dimethylsiloxane)-coated capillaries and microchips. J Chromatogr A, 2002, 947: 277–286

    Article  Google Scholar 

  22. Pallandre A, Lambert B, Attia R, et al. Surface treatment and characterization: Perspectives to electrophoresis and lab-on-chips. Electrophoresis, 2006, 27: 584–610

    Article  Google Scholar 

  23. Wu D P, Qin J H, Lin B C. Self-assembled epoxy-modified polymer coating on a poly(dimethylsiloxane) microchip for EOF inhibition and biopolymers separation. Lab Chip, 2007, 7: 1490–1496

    Article  Google Scholar 

  24. Tan W, Desai T A. Layer-by-layer microfluidics for biomimetic threedimensional structures. Biomaterials, 2004, 25: 1355–1364

    Article  Google Scholar 

  25. Cheng A K H, Ge B X, Yu H Z. Aptamer-based biosensors for babel-free voltammetric detection of lysozyme. Anal Chem, 2007, 79: 5158–5164

    Article  Google Scholar 

  26. Wu J H, Mathew M C. Contact angle measurements of lubricated silicon wafers and hydrogenated carbon overcoats. Langmuir, 1998, 14: 4929–4934

    Article  Google Scholar 

  27. Ren S L, Yang S R, Xue Q J. Perfluorodecanoic acid ultra-thin film on single crystal silicon substrate coated with polyethyleneimine. Acta Phys Chim Sin, 2001,17(2): 97–100

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Life Science and Technology, Beijing Institute of Technology, Beijing, 100081, China

    Yao Xie, LiNa Geng, Feng Qu, AiQin Luo, Feng Qu & YuLin Deng

Authors
  1. Yao Xie
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. LiNa Geng
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Feng Qu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. AiQin Luo
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Feng Qu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. YuLin Deng
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to YuLin Deng.

Additional information

Supported by the National Natural Science Foundation of China (Grant No. 20435020, 20275005 and 20705005)

About this article

Cite this article

Xie, Y., Geng, L., Qu, F. et al. Preparation and characterization of 3-(triethoxysilyl) propyl isocyanate self-assembled monolayer on surface of chip. Chin. Sci. Bull. 54, 738–742 (2009). https://doi.org/10.1007/s11434-009-0059-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11434-009-0059-9

Keywords

Search

Navigation