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Advances in regulation and function of stearoyl-CoA desaturase 1 in cancer, from bench to bed

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Abstract

Stearoyl-CoA desaturase 1 (SCD1) converts saturated fatty acids to monounsaturated fatty acids. The expression of SCD1 is increased in many cancers, and the altered expression contributes to the proliferation, invasion, sternness and chemoresistance of cancer cells. Recently, more evidence has been reported to further support the important role of SCD1 in cancer, and the regulation mechanism of SCD1 has also been focused. Multiple factors are involved in the regulation of SCD1, including metabolism, diet, tumor microenvironment, transcription factors, non-coding RNAs, and epigenetics modification. Moreover, SCD1 is found to be involved in regulating ferroptosis resistance. Based on these findings, SCD1 has been considered as a potential target for cancer treatment. However, the resistance of SCD1 inhibition may occur in certain tumors due to tumor heterogeneity and metabolic plasticity. This review summarizes recent advances in the regulation and function of SCD1 in tumors and discusses the potential clinical application of targeting SCD1 for cancer treatment.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (81672091, 91749107, 81972966, 82272745, 31925021, 82203102), and the National Key Research and Development Program of China (2022YFA1104001).

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Authors and Affiliations

  1. Center of Basic Medical Research, Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, 100191, China

    Zhengyang Guo, Xiao Huo, Xianlong Li, Changtao Jiang & Lixiang Xue

  2. Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Peking University and the Key Laboratory of Molecular Cardiovascular Science (Peking University), Ministry of Education, Beijing, 100191, China

    Changtao Jiang

  3. Peking University Third Hospital Cancer Center, Department of Radiation Oncology, Peking University Third Hospital, Beijing, 100191, China

    Lixiang Xue

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  1. Zhengyang Guo
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Guo, Z., Huo, X., Li, X. et al. Advances in regulation and function of stearoyl-CoA desaturase 1 in cancer, from bench to bed. Sci. China Life Sci. 66, 2773–2785 (2023). https://doi.org/10.1007/s11427-023-2352-9

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