Abstract
Stem cells are undifferentiated cells capable of self-renewal and differentiation, giving rise to specialized functional cells. Stem cells are of pivotal importance for organ and tissue development, homeostasis, and injury and disease repair. Tissue-specific stem cells are a rare population residing in specific tissues and present powerful potential for regeneration when required. They are usually named based on the resident tissue, such as hematopoietic stem cells and germline stem cells. This review discusses the recent advances in stem cells of various tissues, including neural stem cells, muscle stem cells, liver progenitors, pancreatic islet stem/progenitor cells, intestinal stem cells, and prostate stem cells, and the future perspectives for tissue stem cell research.
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Acknowledgements
This work was supported by grants from the National Natural Science Foundation of China (31988101 and 31730056 to YGC; 32125013 and 81772723 to DG; 32170804 to PH; 31930030 to LH; 91732301, 31671072,31771140, 81891001, 91432111, 81527901, 31400977, 31625013 to XW; 31625020, 31830056, 31861163006 to YAZ), the Ministry of Science and Technology of China (2017YFA0103601 to YGC; 2020YFA0509000, 2017YFA0505500 to DG; 2017YFA0102700 to PH; 2019YFA0802001, 2019YFA0801503 to LH; 2017YFA0102601, 2019YFA0110100 to XW; 2020YFA0509002, 2019YFA0802002 to YAZ), the Strategic Priority Research Program of the Chinese Academy of Science (XDA16020400 to PH; XDA16020200 to YAZ), the Shanghai Science and Technology Commission (21XD1424200, 21ZR1470100 to DG), the Basic Frontier Science Research Program of Chinese Academy of Sciences (ZDBS-LY-SM015 to DG), Space Medical Experiment Project of China Manned Space Program (HYZHXM01017 to PH), and the Grants of Beijing Brain Initiative of Beijing Municipal Science & Technology Commission (Z181100001518004 to XW).
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Fu, X., He, Q., Tao, Y. et al. Recent advances in tissue stem cells. Sci. China Life Sci. 64, 1998–2029 (2021). https://doi.org/10.1007/s11427-021-2007-8
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DOI: https://doi.org/10.1007/s11427-021-2007-8