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The association of cerebrospinal fluid pressure with optic nerve head and macular vessel density

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Abstract

The present study aims to investigate the effect of temporary cerebrospinal fluid pressure (CSFP) reduction on optic nerve head (ONH) and macular vessel density (VD) using optical coherence tomography angiography. Forty-four eyes of 44 adults with diagnostic lumbar puncture and CSFP reduction were recruited. Thirty-two eyes of 32 healthy volunteers were controls. ONH and macular VD images were evaluated differences between baseline and after CSFP reduction. The results showed that the mean CSFP decreased from (11.6±2.1) mmHg to (8.2±3.4) mmHg (P<0.001). VD in the macular regions decreased significantly after CSFP reduction in the study group (all P<0.05). The control group showed no significant changes in macular VD (all P>0.05). In the study group, decreased VD in the macular parainferior region was associated with CSFP reduction (R2=0.192, P=0.003), the reduction of macular VD in parafoveal (R2=0.098, P=0.018), parainferior (R2=0.104, P=0.021), parasuperior (R2=0.059, P=0.058), paranasal (R2=0.057, P=0.042), paratemporal (R2=0.079, P=0.026) was associated with mean ocular perfusion pressure decrease following CSFP reduction. ONH vessel density did not differ after CSFP reduction (all P>0.05). In conclusion, macular vessel density decreased in association with CSFP reduction. Retinal vessel density in the macular region is more sensitive than that in peripapillary region after CSFP reduction.

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Acknowledgements

The authors thank the participants of the present study for their contribution: Jing Wang, Zhangfang Ma, and the Beijing iCOP study group.

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Authors and Affiliations

  1. Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China

    Xiangxiang Liu, Danting Lin, Yunxiao Sun, Qing Zhang & Ningli Wang

  2. Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, 33136, USA

    Xiangxiang Liu, Mohamed M. Khodeiry & Richard K. Lee

  3. Research institute of Ophthalmology, Giza, 12557, Egypt

    Mohamed M. Khodeiry

  4. Beijing Ophthalmology and Visual Science Key Laboratory, Beijing Eye Institute, Beijing, 100730, China

    Xiangxiang Liu, Danting Lin, Yunxiao Sun, Qing Zhang & Ningli Wang

  5. Department of Neurology and Medical Research Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China

    Jiawei Wang

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  1. Xiangxiang Liu
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  2. Mohamed M. Khodeiry
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  3. Danting Lin
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  5. Qing Zhang
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  8. Ningli Wang
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Correspondence to Ningli Wang.

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Liu, X., Khodeiry, M.M., Lin, D. et al. The association of cerebrospinal fluid pressure with optic nerve head and macular vessel density. Sci. China Life Sci. 65, 1171–1180 (2022). https://doi.org/10.1007/s11427-021-1984-5

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  • DOI: https://doi.org/10.1007/s11427-021-1984-5

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