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α-Synuclein aggregation and transmission in Parkinson’s disease: a link to mitochondria and lysosome

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Abstract

The presence of intraneuronal Lewy bodies (LBs) and Lewy neurites (LNs) in the substantia nigra (SN) composed of aggregated α-synuclein (α-syn) has been recognized as a hallmark of pathological changes in Parkinson’s disease (PD). Numerous studies have shown that aggregated α-syn is necessary for neurotoxicity. Meanwhile, the mitochondrial and lysosomal dysfunctions are associated with α-syn pathogenicity The hypothesis that α-syn transmission in the human brain contributes to the instigation and progression of PD has provided insights into PD pathology. This review will provide a brief overview of increasing researches that shed light on the relationship of α-syn aggregation with mitochondrial and lysosomal dysfunctions, and highlight recent understanding of α-syn transmission in PD pathology.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (31871023, 31970966), the National Key Scientific Research and Development Program of China (2016YFC1306000), Suzhou Clinical Research Center of Neurological Disease (Szzx201503), and the Priority Academic Program Development of Jiangsu Higher Education Institutions.

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  1. Laboratory of Molecular Neuropathology, Jiangsu Key Laboratory of Neuropsychiatric Diseases & Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, 215123, China

    Rui Wang, Hongyang Sun, Haigang Ren & Guanghui Wang

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Wang, R., Sun, H., Ren, H. et al. α-Synuclein aggregation and transmission in Parkinson’s disease: a link to mitochondria and lysosome. Sci. China Life Sci. 63, 1850–1859 (2020). https://doi.org/10.1007/s11427-020-1756-9

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