Abstract
Chronic obstructive pulmonary disease (COPD), lung cancer (LC) and tuberculosis (TB) are common chronic lung diseases that generate a large disease burden and significant health care resource use in China. The aim of this study was to quantify spatial patterns and effects of air pollution and meteorological factors on hospitalization of COPD, LC and TB in Beijing. Daily counts of hospitalization for 2010 were obtained from the Beijing Urban Employees Basic Medical Insurance (UEBMI) system. Bayesian hierarchical Poisson regression models were applied to identify spatial patterns of hospitalization for COPD, LC and TB at the district level and explore associations with inhalable particulate matter (aerodynamic diameter <10 μm, PM10), sulfur dioxide (SO2), nitrogen dioxide (NO2), mean temperature and relative humidity. There were 18,882, 14,295 and 2,940 counts of hospitalizations for COPD, LC and TB respectively, in Beijing in 2010. Clusters of high relative risk were in different locations for the three diseases. The effect of relative humidity on COPD hospitalization was most significant with a relative risk (RR) of 1.070 (95%CI: 1.054, 1.086) per one percent increase. For lung cancer hospitalization, exposure to ambient SO2 was associated with a RR of 1.034 (95%CI: 1.011, 1.058) per μg m–3 increase. For tuberculosis, the effect of mean temperature was significant with a RR of 1.107 (95%CI: 1.038, 1.180) per °C increase. Risk factors and spatial patterns were different for hospitalization of non-infectious and infectious chronic lung disease in Beijing. Even over a short time period (one year), associations were apparent with air pollution and meteorological factors.
Similar content being viewed by others
References
Arbex, M.A., de Souza Conceição, G.M., Cendon, S.P., Arbex, F.F., Lopes, A.C., Moysés, E.P., Santiago, S.L., Saldiva, P.H.N., Pereira, L.A.A., and Braga, A.L.F. (2009). Urban air pollution and chronic obstructive pulmonary disease-related emergency department visits. J Epidemiol Commun Health 63, 777–783.
Arundel, A.V., Sterling, E.M., Biggin, J.H., and Sterling, T.D. (1986). Indirect health effects of relative humidity in indoor environments. Environ Health Per 65, 351–361.
Chen, X., Zhang, L.W., Huang, J.J., Song, F.J., Zhang, L.P., Qian, Z.M., Trevathan, E., Mao, H.J., Han, B., Vaughn, M., et al. (2016). Long-term exposure to urban air pollution and lung cancer mortality: a 12-year cohort study in Northern China. Sci Total Environ 571, 855–861.
Dominici, F., Peng, R.D., Bell, M.L., Pham, L., McDermott, A., Zeger, S. L., and Samet, J.M. (2006). Fine particulate air pollution and hospital admission for cardiovascular and respiratory diseases. JAMA 295, 1127–1134.
Dong, Y.H., Chang, C.H., Wu, F.L.L., Shen, L.J., Calverley, P.M.A., Löfdahl, C.G., Lai, M.S., and Mahler, D.A. (2014). Use of inhaled corticosteroids in patients with COPD and the risk of TB and influenza. Chest 145, 1286–1297.
Du, Q., Zhang, M., Li, Y., Luan, H., Liang, S., and Ren, F. (2016). Spatial patterns of ischemic heart disease in Shenzhen, china: a Bayesian multidisease modelling approach to inform health planning policies. Int J Environ Res Public Health 13, 436.
Guo, Y., Ma, Y., Zhang, Y., Huang, S., Wu, Y., Yu, S., Zou, F., and Cheng, J. (2017). Time series analysis of ambient air pollution effects on daily mortality. Environ Sci Pollut Res 24, 20261–20272.
Guo, Y., Zeng, H., Zheng, R., Li, S., Barnett, A.G., Zhang, S., Zou, X., Huxley, R., Chen, W., and Williams, G. (2016). The association between lung cancer incidence and ambient air pollution in China: a spatiotemporal analysis. Environ Res 144, 60–65.
Han, J., Liu, S., Zhang, J., Zhou, L., Fang, Q., Zhang, J., and Zhang, Y. (2017). The impact of temperature extremes on mortality: a time-series study in Jinan, China. BMJ Open 7, e014741.
Holt, J.B., Zhang, X., Presley-Cantrell, L., and Croft, J.B. (2011). Geographic disparities in chronic obstructive pulmonary disease (COPD) hospitalization among Medicare beneficiaries in the United States. Int J Chron Obstruct Pulmon Dis 6, 321–328.
Hong, Q.Y., Wu, G.M., Qian, G.S., Hu, C.P., Zhou, J.Y., Chen, L.A., Li, W. M., Li, S.Y., Wang, K., Wang, Q., et al. (2015). Prevention and management of lung cancer in China. Cancer 121, 3080–3088.
Humpel, N., Owen, N., and Leslie, E. (2002). Environmental factors associated with adults’ participation in physical activity A review. Am J Prevent Med 22, 188–199.
Hwang, S., Kang, S., Lee, J.Y., Lee, J.S., Kim, H.J., Han, S.K., and Yim, J. J. (2014). Impact of outdoor air pollution on the incidence of tuberculosis in the Seoul metropolitan area, South Korea. Korean J Intern Med 29, 183–190.
Khalaj, B., Lloyd, G., Sheppeard, V., and Dear, K. (2010). The health impacts of heat waves in five regions of New South Wales, Australia: a case-only analysis. Int Arch Occup Environ Health 83, 833–842.
Ma, Y., Zhao, Y., Yang, S., Zhou, J., Xin, J., Wang, S., and Yang, D. (2017). Short-term effects of ambient air pollution on emergency room admissions due to cardiovascular causes in Beijing, China. Environ Pollut 230, 974–980.
McMichael, A.J., and Woodward, A. (1995). Environmental health. Hazardous environments: local and global. Lancet 346 Suppl, s5.
Mu, Z., Chen, P.L., Geng, F.H., Ren, L., Gu, W.C., Ma, J.Y., Peng, L., and Li, Q.Y. (2017). Synergistic effects of temperature and humidity on the symptoms of COPD patients. Int J Biometeorol 61, 1919–1925.
Onozuka, D., and Hagihara, A. (2015). The association of extreme temperatures and the incidence of tuberculosis in Japan. Int J Biometeorol 59, 1107–1114.
Ping, J. (2015). Influence of hazy weather on patient presentation with respiratory diseases in Beijing, China. Asian Pac J Cancer Prevent 16, 607–611.
Raaschou-Nielsen, O., Andersen, Z.J., Beelen, R., Samoli, E., Stafoggia, M., Weinmayr, G., Hoffmann, B., Fischer, P., Nieuwenhuijsen, M.J., Brunekreef, B., et al. (2013). Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE). Lancet Oncol 14, 813–822.
Rodríguez-Prieto, V., Martínez-López, B., Barasona, J.A., Acevedo, P., Romero, B., Rodriguez-Campos, S., Gortázar, C., Sánchez-Vizcaíno, J. M., and Vicente, J. (2012). A Bayesian approach to study the risk variables for tuberculosis occurrence in domestic and wild ungulates in South Central Spain. BMC Vet Res 8, 148.
Sifaki-Pistolla, D., Lionis, C., Koinis, F., Georgoulias, V., Tzanakis, N., and Tzanakis, N. (2017). Lung cancer and annual mean exposure to outdoor air pollution in Crete, Greece. Eur J Cancer Prevent 26, S208–S214.
Song, Q., Christiani, D.C., XiaorongWang, D.C., and Ren, J. (2014). The global contribution of outdoor air pollution to the incidence, prevalence, mortality and hospital admission for chronic obstructive pulmonary disease: a systematic review and meta-analysis. Int J Environ Res Public Health 11, 11822–11832.
Wang, W., Ying, Y., Wu, Q., Zhang, H., Ma, D., and Xiao, W. (2015). A GIS-based spatial correlation analysis for ambient air pollution and AECOPD hospitalizations in Jinan, China. Respirat Med 109, 372–378.
Wang, Y., Han, Y., Zhu, T., Li, W., and Zhang, H. (2018). A prospective study (SCOPE) comparing the cardiometabolic and respiratory effects of air pollution exposure on healthy and pre-diabetic individuals. Sci China Life Sci 61, 46–56.
Wangdi, K., and Clements, A.C. (2017). Spatial and temporal patterns of diarrhoea in Bhutan 2003–2013. BMC Infect Dis 17, 507.
Wei, Z., Wang, L., Ma, S., Zhang, F., and Yang, J. (2015). Source contributions of PM2.5 in the severe haze episode in Hebei cities. Sci World J 2015, 1–11.
Wu, D., Xu, Y., and Zhang, S. (2015). Will joint regional air pollution control be more cost-effective? An empirical study of China’s Beijing- Tianjin-Hebei region. J Environ Manage 149, 27–36.
Yun, Y., Gao, R., Yue, H., Li, G., Zhu, N., and Sang, N. (2015). Synergistic effects of particulate matter (PM10) and SO2 on human non-small cell lung cancer A549 via ROS-mediated NF-κB activation. J Environ Sci 31, 146–153.
Zeng, Q., Li, G., Zhao, L., Jiang, G., and Pan, X. (2015). Characteristics of the exposure-response relationship of particulate matter and mortality. J Occupat Environ Med 57, e93–e100.
Zhang, S., Li, G., Tian, L., Guo, Q., and Pan, X. (2016). Short-term exposure to air pollution and morbidity of COPD and asthma in East Asian area: a systematic review and meta-analysis. Environ Res 148, 15–23.
Zhang, X., Hao, Y., Fei, Z., and He, J. (2015). Effect of meteorological factors on incidence of tuberculosis: a 15-year retrospective study based on Chinese medicine theory of five circuits and six qi. Chin J Integr Med 21, 751–758.
Zhu, R., Chen, Y., Wu, S., Deng, F., Liu, Y., and Yao, W. (2013). The relationship between particulate Matter (PM10) and hospitalizations and mortality of chronic obstructive pulmonary disease: a meta-analysis. COPD-J Chronic Obstruct Pulmon Dis 10, 307–315.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Compliance and ethics The author(s) declare that they have no conflict of interest.
Rights and permissions
About this article
Cite this article
Tian, L., Yang, C., Zhou, Z. et al. Spatial patterns and effects of air pollution and meteorological factors on hospitalization for chronic lung diseases in Beijing, China. Sci. China Life Sci. 62, 1381–1388 (2019). https://doi.org/10.1007/s11427-018-9413-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11427-018-9413-y