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Nanotherapeutic approaches targeting angiogenesis and immune dysfunction in tumor microenvironment

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Abstract

Tumor microenvironment (TME) comprising cellular and non-cellular components is a major source of cancer hallmarks. Notably, angiogenesis responsible for normal physiological remodeling process can otherwise harness vessel abnormalities during tumorigenesis eliciting severe therapeutic inefficiency. Currently, FDA approved antiangiogenic drugs have only shown modest clinical success owing to tumor hypoxia, antiangiogenic therapeutic resistance, and limited knowledge in understanding TME. In order to overcome these limitations, targeting angiogenesis combined with immunosuppressive TME could offer potential therapeutic opportunities. Indeed, these therapeutic approaches can be further revisited with the advent of nanotechnology that can target the key cellular components of TME and tumor cells more precisely. Synergetic targeting without eliciting systemic toxicity achieved by integration of antiangiogenic and immunotherapy in a single nanoplatform is vital for therapeutic success. In this review, we will discuss the most promising nanotechnological advancements oriented to modulate the immunosuppressive TME in association with antiangiogenic therapy that has gained immense popularity in cancer treatment.

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Acknowledgements

This work was supported by National Key Research and Development Program of China (2016YFA0201400) and the Foundation for Innovative Research Groups of the National Natural Science Foundation of China (81421004).

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  1. Department of Biomedical Engineering, College of Engineering, Peking University, Beijing, 100871, China

    Sadaf Hameed, Pravin Bhattarai & Zhifei Dai

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Hameed, S., Bhattarai, P. & Dai, Z. Nanotherapeutic approaches targeting angiogenesis and immune dysfunction in tumor microenvironment. Sci. China Life Sci. 61, 380–391 (2018). https://doi.org/10.1007/s11427-017-9256-1

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