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Characteristics of distribution of Mycobacterium tuberculosis lineages in China

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Abstract

The genotyping methods of Mycobacterium tuberculosis would dramatically improve our understanding of the molecular epidemiology of tuberculosis. 3,929 isolates, from a National Survey of Drug-Resistant Tuberculosis in 2007 in China, were successfully genotyped by large sequence polymorphisms and 15 loci variable number tandem repeats. We found that 2,905 (2,905/3,929, 73.9%) cases belonged to Lineage 2, dominated in the east and central regions, 975 cases (975/3,929, 24.8%) were Lineage 4, highly prevailed in the west regions, and 36 and 13 cases were Lineage 3 and Lineage 1, respectively. We also explored the associations between lineages (Lineage 2 vs. Lineage 4) and clinical characteristics by logistic regression. For Lineage 2, the risk factors were Han-ethnicity population and fever. However, for Lineage 4, they were occupation (farmer), and degree of education (non-literate). Fully understanding of the distribution of Mycobacterium tuberculosis lineage and its risk factors would play a critical role in tuberculosis prevention, control, and treatment.

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Acknowledgements

We thank Professor Getu Zhaori, who was an academic editor of New England Journal of Medicine for polishing the manuscript. We also thank Professor Yanlin Zhao for leading the National Survey of Drug-Resistant Tuberculosis in 2007, in China. This work was supported by the National Natural Science Foundation of China (81273144), Beijing Natural Science Foundation Program and Scientific Research Key Program of Beijing Municipal Commission of Education (KZ201510025024), the Fundamental Research Funds for the Central Universities (2017JBM071) and the China Postdoctoral Science Foundation (2017M620595).

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  1. Contributed equally to this work

Authors and Affiliations

  1. Zhejiang Provincial Key Laboratory for Technology and Application of Model Organisms, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, 325035, China

    Haixia Chen, Jingyi Liu & Jimin Gao

  2. National Tuberculosis Clinical Lab of China, Beijing Tuberculosis and Thoracic Tumor Research Institute; Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China

    Haixia Chen, Jingyi Liu, Junnan Jia, Hairong Huang & Weimin Li

  3. Academy of Mathematics and Systems Science, Chinese Academy of Sciences, Beijing, 100190, China

    Li He

  4. School of Mathematical Sciences, Univsersity of Chinese Academy of Sciences, Beijing, 100049, China

    Li He

  5. Beijing Key Laboratory in Drug Resistance Tuberculosis Research, Beijing Chest Hospital, Capital Medical University, Beijing, 101149, China

    Chao Cai, Junnan Jia, Hairong Huang & Weimin Li

  6. Beijing Municipal Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, 100069, China

    Junnan Jia & Weimin Li

  7. Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, 100101, China

    Liang Ma

  8. National Center for Tuberculosis Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China

    Lixia Wang

  9. Department of Mathematics, School of Science, Beijing Jiaotong University, Beijing, 100044, China

    Xumin Ni

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  1. Haixia Chen
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Correspondence to Xumin Ni, Jimin Gao or Weimin Li.

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Chen, H., He, L., Cai, C. et al. Characteristics of distribution of Mycobacterium tuberculosis lineages in China. Sci. China Life Sci. 61, 651–659 (2018). https://doi.org/10.1007/s11427-017-9243-0

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  • DOI: https://doi.org/10.1007/s11427-017-9243-0

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