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D’Alia D, Nieselt K, Steigele S, et al. Noncoding RNA of glutamine synthetase I modulates antibiotic production in Streptomyces coelicolor A3(2). J Bacteriol, 2010, 192: 1160–1164
Reyes-Dominguez Y, Bok J W, Berger H, et al. Heterochromatic marks are associated with the repression of secondary metabolism clusters in Aspergillus nidulans. Mol Microbiol, 2010, 76: 1376–1386
Speck P. Antibiotics: avert an impending crisis. Nature, 2013, 496: 169
Lu W, Roongsawang N, Mahmud T. Biosynthetic studies and genetic engineering of pactamycin analogs with improved selectivity toward malarial parasites. Chem Biol, 2011, 18: 425–431
Kaysser L, Lutsch L, Siebenberg S, et al. Identification and manipulation of the caprazamycin gene cluster lead to new simplified liponucleoside antibiotics and give insights into the biosynthetic pathway. J Biol Chem, 2009, 284: 14987–14996
Li J, Li L, Tian Y, et al. Hybrid antibiotics with the nikkomycin nucleoside and polyoxin peptidyl moieties. Metab Eng, 2011, 13: 336–344
Pfeifer B A, Admiraal S J, Gramajo H, et al. Biosynthesis of complex polyketides in a metabolically engineered strain of E. coli. Science, 2001, 291: 1790–1792
Komatsu M, Uchiyama T, Omura S, et al. Genome-minimized Streptomyces host for the heterologous expression of secondary metabolism. Proc Natl Acad Sci USA, 2010, 107: 2646–2651
Liu G, Chater K F, Chandra G, et al. Molecular regulation of antibiotic biosynthesis in Streptomyces. Microbiol Mol Biol Rev, 2013, 77: 112–143
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Biographical Sketch Niu GuoQing obtained his Ph.D. in microbial genetics in 2006 at the Institute of Microbiology, Chinese Academy of Sciences (CAS). After graduation he worked for four years as an Associate Research Scholar at the University of Oklahoma Health Sciences Center, USA. In 2010, he was appointed Associate Professor in molecular microbiology at the Institute of Microbiology, CAS. His research focuses on the molecular regulation of secondary metabolites in Streptomyces. From 2006 to the present, he has published 15 research papers.
Biographical Sketch Tan HuaRong obtained his Ph.D. in microbial genetics in 1991 at the University of East Anglia, England. In 1992, he started to work on the molecular regulation of differentiation and secondary metabolites in Streptomyces. In 1994, he was appointed as a Full Professor in molecular microbiology at the Institute of Microbiology, Chinese Academy of Sciences (CAS). From1999 to 2008, he served as the Deputy Director of the Institute of Microbiology, CAS. From 2001 to 2011, he was a Vice President of the Chinese Society for Microbiology. From 2006 to the present, he has been an Editor in Chief for Acta Microbiologica Sinica. He has published more than 120 papers in his research field.
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Niu, G., Tan, H. Biosynthesis and regulation of secondary metabolites in microorganisms. Sci. China Life Sci. 56, 581–583 (2013). https://doi.org/10.1007/s11427-013-4501-5
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DOI: https://doi.org/10.1007/s11427-013-4501-5