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Retrovirus-mediated delivery of an IL-4 receptor antagonist inhibits allergic responses in a murine model of asthma

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Abstract

This work reports the investigation of the effect of airway IL-4RA gene transfer by a recombinant retroviral vector on airway inflammation and airway responsiveness in asthmatic mice. The retrovirus-mediated delivery of IL-4RA to the airways of mice inhibited elevations of airway responsiveness and the development of allergic inflammation in asthmatic mice, and regulated the Th1/Th2 balance in OVA-sensitized and -challenged mouse models. This suggests that gene therapy is a therapeutic option for treating and controlling chronic airway inflammation and asthma symptoms.

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Authors and Affiliations

  1. Department of Pediatrics, Zhongshan Boai Hospital, Zhongshan, 528403, China

    GuiLan Wang

  2. Department of Pediatrics, First Hospital, Jilin University, Changchun, 130021, China

    JiRong Lu

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  1. GuiLan Wang
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  2. JiRong Lu
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Correspondence to JiRong Lu.

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Wang, G., Lu, J. Retrovirus-mediated delivery of an IL-4 receptor antagonist inhibits allergic responses in a murine model of asthma. Sci. China Life Sci. 53, 1215–1220 (2010). https://doi.org/10.1007/s11427-010-4067-4

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  • DOI: https://doi.org/10.1007/s11427-010-4067-4

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