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TRAF-mediated regulation of immune and inflammatory responses

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Abstract

The tumor necrosis factor (TNF) receptor-associated factor (TRAF) family consists of six mammalian members, and is shown to participate in signal transduction of a large number of receptor families including TNF receptor family (TNFR) and Toll-like receptors-interleukin-1 receptors (TLR-IL-1R) family. Upon receptor activation, TRAFs are directly or indirectly recruited to the intracellular domains of these receptors. They subsequently engage other signaling proteins to activate inhibitor of κB kinase (IKK) complex, TRAF family member-associated NF-κB activator (TANK)-binding kinase 1 (TBK1) and inducible I κB kinase (IKK-i) (also known as IKKɛ), ultimately leading to activation of transcription factors such as NF-κB and interferon-regulatory factor (IRF) to induce immune and inflammatory responses.

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Authors and Affiliations

  1. Department of Microbiology, Immunology & Molecular Genetics, University of California Los Angeles, 609 Charles E. Young Drive East, Los Angeles, California, 90095, USA

    YaYa Wang & GenHong Cheng

  2. National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China

    Peng Zhang & YingFang Liu

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  1. YaYa Wang
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  2. Peng Zhang
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  3. YingFang Liu
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  4. GenHong Cheng
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Correspondence to GenHong Cheng.

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Wang, Y., Zhang, P., Liu, Y. et al. TRAF-mediated regulation of immune and inflammatory responses. Sci. China Life Sci. 53, 159–168 (2010). https://doi.org/10.1007/s11427-010-0050-3

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  • DOI: https://doi.org/10.1007/s11427-010-0050-3

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