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Structural immunology of costimualtory and coinhibitory molecules

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Abstract

The T cell costimulatory pathways are central to regulating immune responses, and targeting these pathways represents one of the most promising approaches for achieving immunotherapy. The molecular structures of costimulation revealed invaluable mechanistic insights underlying costimulatory receptor/ligand specificity, affinity, oligomeric state, and valency, which provided the bases for better manipulation of these signaling pathways. The incredible growth of this field led to identification of new members and unexpected interactions, revealing a complicated regulatory network of immune responses. The advances in structural biology of costimulation will promise unprecedented opportunities for furthering our understanding and therapeutic application of T cell costimulatory pathways.

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Authors and Affiliations

  1. Center for Infection and Immunity, Institute of Biophysics, Chinese Academy of Sciences, Beijing, 100101, China

    ShengDian Wang & LiePing Chen

  2. Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

    LiePing Chen

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  1. ShengDian Wang
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Correspondence to ShengDian Wang.

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Wang, S., Chen, L. Structural immunology of costimualtory and coinhibitory molecules. Sci. China Life Sci. 53, 183–189 (2010). https://doi.org/10.1007/s11427-010-0043-2

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