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Immediate-early gene product ICP22 inhibits the trans-transcription activating function of P53-mdm-2

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Abstract

As a product of HSVI immediate-early gene, ICP22 is capable of interacting with various cellular transcriptive and regulatory molecules during viral infection so as to impact the normal cellular molecular mechanism. ICP22 expressed in transfected cells can push the cells’ entering into S phase with binding to mdm-1 promoter region and impact its trans-transcription activating effect by P53. Consequently, the MDM-2 binds to P53, and the degradation effects by the ubiquitous pathway are decreased, improving indirectly the P53 levels in cells and making the cells progress into the S phase.

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Authors and Affiliations

  1. Department of Viral Immunology, Institute of Medical Biology, CAMS and PUMC, Kunming, 650118, China

    Guo HongXiong, Cun Wei, Liu LongDing, Wang LiChun, Zhao HongLing, Dong ChengHong & Li QiHan

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  1. Guo HongXiong
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  2. Cun Wei
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  3. Liu LongDing
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  4. Wang LiChun
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  5. Zhao HongLing
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  6. Dong ChengHong
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  7. Li QiHan
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Corresponding author

Correspondence to Li QiHan.

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These authors contributed equally to this work

Supported by the National Natural Science Foundation of China (Grant No. 30570081)

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Guo, H., Cun, W., Liu, L. et al. Immediate-early gene product ICP22 inhibits the trans-transcription activating function of P53-mdm-2. SCI CHINA SER C 50, 473–478 (2007). https://doi.org/10.1007/s11427-007-0039-8

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  • DOI: https://doi.org/10.1007/s11427-007-0039-8

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