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Attractive natural products with strained cyclopropane and/or cyclobutane ring systems

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Abstract

The strained cyclopropane and/or cyclobutane subunits occurred in many complex natural products including terpenoids, steroids and alkaloids. Natural products with cyclopropane and/or cyclobutane motifs not only furnished fascinating structures, but also exhibited versatile biological activities, such as cytotoxic, anti-HIV, antimicrobial, antiviral, and immunosuppressive effects. This review covered a large array of structurally unique natural products with strained cyclopropane and/or cyclobutane motifs and summarized their structural features, distributions, biological activities, as well as biogenetic considerations.

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Authors and Affiliations

  1. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China

    Yao-Yue Fan, Xin-Hua Gao & Jian-Min Yue

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  1. Yao-Yue Fan
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  2. Xin-Hua Gao
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  3. Jian-Min Yue
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Correspondence to Jian-Min Yue.

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Fan, YY., Gao, XH. & Yue, JM. Attractive natural products with strained cyclopropane and/or cyclobutane ring systems. Sci. China Chem. 59, 1126–1141 (2016). https://doi.org/10.1007/s11426-016-0233-1

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